 |
|
Dietary Fatty Acids and the 5-Year Incidence of Age-Related Maculopathy
Brian Chua, BSc, MBBS, MPH;
Victoria Flood, MPH, PhD;
Elena Rochtchina, MApplStat;
Jie Jin Wang, MMed, PhD;
Wayne Smith, MPH, PhD;
Paul Mitchell, MD, PhD, FRANZCO, FAFPHM
Arch Ophthalmol. 2006;124:981-986.
Objective To assess longitudinal associations between dietary fat and incident age-related maculopathy (ARM) in an older, population-based, historical cohort.
Methods A total of 3654 persons, 49 years or older, participated in the Blue Mountains Eye Study (1992-1994); 2335 (75.1% of survivors) were reexamined after 5 years (1997-1999). Dietary data were collected from 2895 people (79%) at baseline by means of a semiquantitative food frequency questionnaire to calculate dietary fat intakes. Presence of ARM was graded from retinal photographs (Wisconsin ARM Grading System). Logistic regression adjusted for age, sex, vitamin C intake, and smoking.
Results Participants with the highest vs lowest quintiles of n-3 polyunsaturated fat intake had lower risk of incident early ARM (odds ratio [95% confidence interval], 0.41 [0.22-0.75). A 40% reduction of incident early ARM was associated with fish consumption at least once a week (odds ratio [95% confidence interval], 0.58 [0.37-0.90]), whereas fish consumption at least 3 times per week could reduce the incidence of late ARM (odds ratio [95% confidence interval], 0.25 [0.06-1.00]). We found no association between incident ARM and butter, margarine, or nut consumption.
Conclusions A regular diet high in n-3 polyunsaturated fat, especially from fish, suggests protection against early and late ARM in this older Australian cohort. Our study could not confirm deleterious effects of higher polyunsaturated fat intakes reported by other clinic-based studies.
Author Affiliations: Centre for Vision Research, Department of Ophthalmology, University of Sydney, Westmead Millennium Institute, and Vision Co-operative Research Centre, Sydney, Australia (Drs Chua, Flood, Wang, and Mitchell and Ms Rochtchina); Centre for Clinical Epidemiology and Biostatistics, University of Newcastle, Newcastle, Australia (Dr Smith); and Departments of Molecular and Microbial Biosciences and Public Health, University of Sydney (Dr Flood).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Association Between Dietary Fat Intake and Age-Related Macular Degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS): An Ancillary Study of the Women's Health Initiative
Parekh et al.
Arch Ophthalmol 2009;127:1483-1493.
ABSTRACT
| FULL TEXT
Dietary Fatty Acids and the 10-Year Incidence of Age-Related Macular Degeneration: The Blue Mountains Eye Study
Tan et al.
Arch Ophthalmol 2009;127:656-665.
ABSTRACT
| FULL TEXT
Fat Consumption and Its Association With Age-Related Macular Degeneration
Chong et al.
Arch Ophthalmol 2009;127:674-680.
ABSTRACT
| FULL TEXT
Combined Effects of Complement Factor H Genotypes, Fish Consumption, and Inflammatory Markers on Long-Term Risk for Age-related Macular Degeneration in a Cohort
Wang et al.
Am J Epidemiol 2009;169:633-641.
ABSTRACT
| FULL TEXT
The Relationship of Dietary {omega}-3 Long-Chain Polyunsaturated Fatty Acid Intake With Incident Age-Related Macular Degeneration: AREDS Report No. 23
SanGiovanni et al.
Arch Ophthalmol 2008;126:1274-1279.
ABSTRACT
| FULL TEXT
Oily fish consumption, dietary docosahexaenoic acid and eicosapentaenoic acid intakes, and associations with neovascular age-related macular degeneration
Augood et al.
Am. J. Clin. Nutr. 2008;88:398-406.
ABSTRACT
| FULL TEXT
Dietary {omega}-3 Fatty Acid and Fish Intake in the Primary Prevention of Age-Related Macular Degeneration: A Systematic Review and Meta-analysis
Chong et al.
Arch Ophthalmol 2008;126:826-833.
ABSTRACT
| FULL TEXT
Contributions of Genetics to Our Understanding of Inherited Monogenic Retinal Diseases and Age-Related Macular Degeneration
Bok
Arch Ophthalmol 2007;125:160-164.
ABSTRACT
| FULL TEXT
|
