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The Blue Mountains Eye Study

Sudha Cugati, MS; Jie Jin Wang, MMed, PhD; Elena Rochtchina, MApplStat; Paul Mitchell, MD, PhD

Arch Ophthalmol. 2006;124:726-732.

Objective  To assess the 10-year incidence of retinal vein occlusion (RVO) and its predictors in an older population.

Methods  The Blue Mountains Eye Study examined 3654 residents aged 49 years and older (82.4% response) from 1992 to 1994, reexamined 2335 residents (75.1% of survivors) from 1997 to 1999, and reexamined 1952 residents (75.6% of survivors) from 2002 to 2004. Incident RVO was assessed from stereoscopic retinal photographs. Kaplan-Meier cumulative 10-year incidence was calculated.

Results  After excluding 47 residents with RVO at baseline and 171 residents with no photographs at either follow-up examination, 2346 residents were considered at risk of developing RVO. The cumulative 10-year incidence of RVO was 1.6%. Age was significantly associated with the incidence of RVO (P = .03, Mantel-Haenszel ² test for trend). Factors predicting the incidence of RVO included mean arterial blood pressure (age-adjusted odds ratio [OR], 1.41 per 10–mm Hg increase), ocular perfusion pressure (OR, 1.71 per 10–mm Hg increase), obesity (OR, 2.16), and presence of retinal arteriolar wall signs (focal narrowing: OR, 3.37; arteriovenous nicking: OR, 4.09; and opacification: OR, 4.89).

Conclusions  Older age (70 years), increasing mean arterial blood pressure, and atherosclerotic retinal vessel signs were significant predictors of incident RVO.

Author Affiliations: Centre for Vision Research, Department of Ophthalmology, University of Sydney, Westmead Hospital, Westmead, Australia.

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