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Taiji Nagaoka, MD, PhD; Atsushi Takahashi, MD; Eiichi Sato, MD, PhD; Naohiro Izumi, MD; Travis W. Hein, PhD; Lih Kuo, PhD; Akitoshi Yoshida, MD, PhD

Arch Ophthalmol. 2006;124:665-670.

Objective  To investigate the effect of systemic administration of simvastatin on the retinal circulation.

Methods  The effects of systemic administration of simvastatin on the retinal circulation after 90 minutes and after 7 days were studied in a placebo-controlled, double-masked, clinical trial among 12 healthy men. We used laser Doppler velocimetry to measure vessel diameter and blood velocity and calculated the blood flow in retinal arteries and veins. We also measured the intraocular pressure and the plasma nitrite/nitrate levels, the stable end products of nitric oxide metabolism.

Results  There were no significant changes in any retinal circulatory parameters at 90 minutes after administration of simvastatin. Daily administration of simvastatin for 7 days significantly increased blood velocity and blood flow in retinal arteries and veins but did not significantly change vessel diameter. The intraocular pressure significantly decreased at 90 minutes and at 7 days after administration of simvastatin. Simvastatin also significantly increased the plasma nitrite/nitrate levels.

Conclusion  Simvastatin induced an increase in blood velocity and blood flow in retinal arteries and veins, increased the plasma nitrite/nitrate levels, and decreased the intraocular pressure, probably through the increase in nitric oxide.

Author Affiliations: Department of Ophthalmology, Asahikawa Medical College, Asahikawa, Japan (Drs Nagaoka, Takahashi, Sato, Izumi, and Yoshida); and Division of Ophthalmology, Department of Surgery, Scott & White Eye Institute, Texas A&M University System Health Science Center, Temple (Drs Nagaoka, Hein, and Kuo).

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