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Prevalence of Age-Related Maculopathy in Older Europeans
The European Eye Study (EUREYE)
Cristina A. Augood, MD;
Johannes R. Vingerling, MD;
Paulus T. V. M. de Jong, MD, PhD;
Usha Chakravarthy, MD, PhD;
Johan Seland, MD;
Gisele Soubrane, MD, PhD;
Laura Tomazzoli, MD;
Fotis Topouzis, MD, PhD;
Graham Bentham, PhD;
Mati Rahu, MD, PhD;
Jesus Vioque, PhD;
Ian S. Young, MBBS, PhD;
Astrid E. Fletcher, PhD
Arch Ophthalmol. 2006;124:529-535.
Objective To estimate the prevalence of age-related maculopathy in an older population from 7 European countries.
Methods Randomly sampled people 65 years and older were invited to an eye examination in centers across 7 European countries (Norway, Estonia, United Kingdom, France, Italy, Greece, and Spain). Fundus images of each eye were graded at a single reading center. Prevalence rates were calculated for stage of age-related maculopathy with 95% confidence intervals (CIs) estimated for clustered data.
Results Of 5040 participants (45% response rate), 4753 (2128 men and 2625 women) had gradable fundus images. The prevalences were grade 0, 47.59% (95% CI, 43.53%-51.65%); grade 1, 36.48% (95% CI, 32.66%-40.30%); grade 2, 10.14% (95% CI, 8.92% to 11.37%); grade 3, 2.46% (95% CI, 1.79%-3.13%); and grade 4 (age-related macular degeneration [AMD]), 3.32% (95% CI, 2.52%-4.13%) and large drusen only ( 125 µm), 15.41% (95% CI, 13.61%-17.21%). The prevalence of geographic atrophic AMD was 1.2% (95% CI, 0.8%-1.7%) and of neovascular AMD, 2.3% (95% CI, 1.7%-2.9%). The prevalence of bilateral AMD was 1.4% (95% CI, 1.0%-1.8%).
Conclusion Age-specific prevalences of age-related maculopathy in the European Eye Study (EUREYE) are similar to other population-based studies in Western populations.
Author Affiliations: Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, England (Drs Augood and Fletcher); Departments of Ophthalmology (Dr Vingerling) and Epidemiology and Biostatistics (Drs Vingerling and de Jong), Erasmus Medical Centre, Rotterdam, and The Netherlands Ophthalmic Research Institute, KNAW, Department of Ophthalmology, Academic Medical Center, Amsterdam (Dr de Jong), the Netherlands; Department of Ophthalmology (Dr Chakravarthy) and Centre for Clinical and Population Sciences (Dr Young), Queen's University of Belfast, Belfast, Northern Ireland, UK; Øyeavdelingen, Haukeland Sykehus University of Bergen, Bergen, Norway (Dr Seland); Clinique Ophtalmologique, Universitaire De Creteil, Paris, France (Dr Soubrane); Clinica Oculistica, Università degli Studi di Verona, Verona, Italy (Dr Tomazzoli); "B" Department of Ophthalmology, Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece (Dr Topouzis); Centre for Environmental Risk, University of East Anglia, Norwich, England (Dr Bentham); Department of Epidemiology and Biostatistics, National Institute for Health Development, Tallinn, Estonia (Dr Rahu); Departamento de Salud Publica Universidad Miguel Hernandez, Alicante, Spain (Dr Vioque).
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