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Nine-Year Incidence of Diabetic Retinopathy in the Barbados Eye Studies
M. Cristina Leske, MD, MPH;
Suh-Yuh Wu, MA;
Anselm Hennis, MRCP(UK), PhD;
Barbara Nemesure, PhD;
Andrew P. Schachat, MD;
Leslie Hyman, PhD;
Ling Yang, MS; for the Barbados Eye Study Group
Arch Ophthalmol. 2006;124:250-255.
Objective To estimate the 9-year incidence of diabetic retinopathy (DR) in a population with the same ancestry as African Americans.
Methods Participants with diabetes mellitus and gradable photographs at the 9-year examination were evaluated (n = 436). The incidences of minimum/moderate/severe DR, clinically significant macular edema (CSME), and sight-threatening DR (severe DR plus CSME) were defined by the development of specific diabetic changes in persons without those conditions at baseline. Progression was defined as the development of severe/proliferative DR in persons with minimum/moderate DR at baseline.
Results The 9-year DR incidence was 39.6% (38.0% for minimum, 9.0% for moderate, and 2.6% for severe/proliferative DR). Incidence tended to increase with diabetes duration and treatment. Of persons with preexisting DR at baseline, 8.2% progressed to proliferative DR. The CSME incidence was 8.7%, and it increased with diabetes duration, accounting for most of the overall incidence of sight-threatening DR.
Conclusions The study provides new data on long-term incidence among persons of African origin. Results suggest a possible lower risk of severe/proliferative DR than in whites, while CSME incidence seems comparable or higher. The main component of sight-threatening DR was CSME, highlighting the importance of DR as a cause of vision loss in this population.
Author Affiliations: Department of Preventive Medicine, Stony Brook University, Stony Brook, NY (Drs Leske, Nemesure, and Hyman and Mss Wu and Yang); Ministry of Health, Bridgetown, and Chronic Disease Research Centre, School of Clinical Medicine and Research, University of the West Indies, Bridgetown, Barbados (Dr Hennis); and Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Md (Dr Schachat).
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