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Effect of Retinal Residua of Retinopathy of Prematurity

Cryotherapy for Retinopathy of Prematurity Cooperative Group^*

Arch Ophthalmol. 2006;124:199-202.

Objective  To describe recognition (letter) acuity at age 10 years in eyes with and without retinal residua of retinopathy of prematurity (ROP).

Design  Presence and severity of ROP residua were documented by a study ophthalmologist. Masked testers measured monocular recognition visual acuity (Early Treatment of Diabetic Retinopathy Study) when the children were 10 years old. Two hundred forty-seven of 255 surviving Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) randomized trial patients participated. A reference group of 102 of 104 Philadelphia-based CRYO-ROP study participants who did not develop ROP was also tested.

Results  More severe retinal residua were associated with worse visual acuity, regardless of whether retinal ablation was performed to treat the severe acute-phase ROP. However, within each ROP residua category, there was a wide range of visual acuity results.

Conclusions  This is the first report of the relation between visual acuity (Early Treatment of Diabetic Retinopathy Study charts) and structural abnormalities related to ROP in a large group of eyes that developed threshold ROP in the perinatal period. Visual deficits are greater in eyes with more severe retinal residua than in eyes with mild or no residua. However, severity of ROP residua does not predict the visual acuity of an individual eye because within a single residua category, acuity may range from near normal to blind.

*Writing Committee: This article was prepared on behalf of the Cryotherapy for Retinopathy of Prematurity Cooperative Group by Velma Dobson, PhD (chair)Graham E. Quinn, MD, MSCEC. Gail Summers, MDRobert J. Hardy, PhD and Betty Tung, MS.
Group Information: A complete list of the members of the Cryotherapy for Retinopathy of Prematurity Cooperative Group at the 10-year examination was published in Arch Ophthalmol (2001;119:1110-1118).

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