• Online Features  This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (21)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Neurology  • Ophthalmological Disorders, Other  • Endocrine Diseases  • Diabetes Mellitus  • Hypertension  • Alert me on articles by topic  Social Bookmarking   What's this?

The Barbados Eye Studies

Sun-Yuh Wu, MA; Barbara Nemesure, PhD; Anselm Hennis, FRCP(UK), PhD; M. Cristina Leske, MD, MPH; for the Barbados Eye Studies Group

Arch Ophthalmol. 2006;124:1631-1636.

Objective  To describe temporal changes in intraocular pressure (IOP) and associated risk factors after 9 years of follow-up in a population of African descent.

Methods  Changes in IOP were evaluated in 2298 participants without glaucoma or IOP-lowering treatment at baseline. Risk factor analyses used a multiple regression approach with mixed effects, which accounted for intereye correlation.

Results  The mean 9-year change in IOP was small, with relatively large dispersion (mean ± SD, 0.4 ± 4.0 mm Hg). Only 6.5% of persons with IOP of 21 mm Hg or less at baseline had elevated IOP greater than 21 mm Hg after 9 years. Mean IOP increases were largest in persons aged 50 to 59 years at baseline (mean ± SD, 0.9 ± 4.3 mm Hg), whereas IOP decreased in persons 70 years or older (mean ± SD, –0.6 ± 4.2 mm Hg). In multivariate analyses, IOP changes were positively associated with male sex, hypertension, diabetes history, and higher systolic and diastolic blood pressure at baseline, as well as with increases in blood pressure throughout 9 years (P<.05).

Conclusions  After long-term follow-up, minimal changes in IOP were observed in this African-origin population. The consistent relationships of hypertension and diabetes to IOP, a major glaucoma risk factor, underscore the public health importance of controlling these systemic conditions in black populations, where glaucoma incidence is high.

Author Affiliations: Department of Preventive Medicine, Stony Brook University, Stony Brook, NY (Wu, Nemesure, Hennis, and Leske); and Ministry of Health (Hennis) and Chronic Disease Research Centre, Tropical Medicine Research Institute, University of the West Indies (Hennis), Barbados, West Indies.

CiteULike    Connotea    Delicious    Digg    Facebook    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Natural History of Intraocular Pressure in the Early Manifest Glaucoma Trial: A 6-Year Follow-up
Hyman et al.
Arch Ophthalmol 2010;128:601-607.
ABSTRACT | FULL TEXT  

Impact of Systemic Blood Pressure on the Relationship between Intraocular Pressure and Blood Flow in the Optic Nerve Head of Nonhuman Primates
Liang et al.
IOVS 2009;50:2154-2160.
ABSTRACT | FULL TEXT  

Ocular and systemic factors related to intraocular pressure in Japanese adults: the Tajimi study
Kawase et al.
Br J Ophthalmol 2008;92:1175-1179.
ABSTRACT | FULL TEXT  

Open-angle Glaucoma and Mortality: The Barbados Eye Studies
Wu et al.
Arch Ophthalmol 2008;126:365-370.
ABSTRACT | FULL TEXT