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Fabio N. Kanadani, MD; Syril Dorairaj, MD; Alan M. Langlieb, MD, MPH, MBA; Wisam A. Shihadeh, MD; Celso Tello, MD; Jeffrey M. Liebmann, MD; Robert Ritch, MD

Arch Ophthalmol. 2006;124:1573-1576.

Objective  To identify differences in anterior chamber anatomy among patients with asymmetric pigment dispersion syndrome and no other discernible cause for the asymmetry.

Methods  Ultrasound biomicroscopy and A-scan biometry were performed on both eyes of 13 patients with asymmetric pigment dispersion syndrome without a known cause for asymmetric involvement. A radial perpendicular image in the horizontal temporal meridian detailing the scleral spur, angle anatomy, and iris configuration was obtained for each eye by 2 examiners.

Results  There were no differences in lens thickness (P = .33), refractive error (P = .84), or axial length (P = .99) between more and less affected eyes. However, the mean ± SD iris concavity (P<.001), iris-lens contact distance (P = .02), and distance from the scleral spur to the iris insertion (0.42 ± 0.11 vs 0.29 ± 0.06 mm) (P = .002) were greater in the more affected eye of each patient.

Conclusion  A more posterior iris insertion predisposes to the phenotypic expression of pigment dispersion syndrome.

Author Affiliations: Department of Ophthalmology, The New York Eye and Ear Infirmary (Drs Kanadani, Dorairaj, Shihadeh, Tello, Liebmann, and Ritch), and Glaucoma Service, Manhattan Eye, Ear & Throat Hospital, Department of Ophthalmology, New York University School of Medicine (Dr Liebmann), New York, and Department of Ophthalmology, New York Medical College, Valhalla (Dr Ritch); and Department of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Md (Dr Langlieb). Dr Kanadani is now with the Department of Ophthalmology, Santa Casa Hospital, University of Minas Gerais, Belo Horizonte, Brazil. Dr Shihadeh is now with the Faculty of Medicine, Jordan University of Science & Technology, Irbid, Jordan.

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