This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on ISI (1)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Glaucoma  • Alert me on articles by topic  Social Bookmarking   What's this?

David B. Henson, PhD; Siddesh Shambhu, MSc, MBBS

Arch Ophthalmol. 2006;124:1405-1408.

Objective  To establish the relative risk of progressive visual field loss in a sample of glaucomatous eyes enrolled in a prospective longitudinal study vs a matched sample of eyes not enrolled in a study.

Methods  The first visual field records of 66 glaucomatous eyes enrolled in a prospective longitudinal study (mean follow-up time, 3.4 years; mean number of visual field tests, 8.3) were matched to 66 eyes from patients not enrolled in a study (mean follow-up time, 3 years; mean number of visual field tests, 3.7). Eyes were matched on the basis of (1) time of enrollment, (2) length of follow-up, and (3) the extent and spatial pattern of visual field loss. Linear regression of global visual field indexes was used to measure change and the relative risk of progression was calculated for a series of progression criteria sample.

Results  The relative risk of progressive visual field loss was on average 368% (range, 209%-673%) higher in the eyes not enrolled in a prospective longitudinal study.

Conclusion  Selection bias may reduce the risk of progressive visual field loss in patients enrolled in longitudinal studies.

Author Affiliations: School of Medicine, University of Manchester, Manchester, England.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Ten-year outcomes in newly diagnosed glaucoma patients: mortality and visual function
Sharma and Salmon
Br. J. Ophthalmol. 2007;91:1282-1284.
ABSTRACT | FULL TEXT