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John L. Keltner, MD; Chris A. Johnson, PhD; Richard A. Levine, PhD; Juanjuan Fan, PhD; Kimberly E. Cello, BS; Michael A. Kass, MD; Mae O. Gordon, PhD; for the Ocular Hypertension Treatment Study Group

Arch Ophthalmol. 2005;123:1201-1206.

Objective  To compare the occurrence of normal visual field (VF) test results following 2 vs 3 consecutive, abnormal, reliable test results in the Ocular Hypertension Treatment Study.

Methods  The Ocular Hypertension Treatment Study is a prospective, multicenter follow-up study as part of a longitudinal randomized clinical trial. Sixty-four (68 eyes) of 1636 participants developed a VF primary open-angle glaucoma (POAG) end point. We compared the proportion of normal VF test results after a VF POAG end point among eyes whose VF abnormality was confirmed by 2 (n = 9 eyes) vs 3 (n = 59 eyes) consecutive, abnormal, reliable VF test results.

Results  The proportion of VF test results that were normal subsequent to a VF POAG end point in eyes whose abnormality was confirmed by 2 consecutive, abnormal, reliable test results was significantly higher (73 [66%] of 110) compared with eyes whose abnormality was confirmed by 3 consecutive, abnormal, reliable test results (46 [12%] of 381) (P = .01).

Conclusions  A VF POAG end point confirmed by 3 consecutive, abnormal, reliable VF test results appears to have greater specificity and stability than either 1 or 2 consecutive, abnormal, reliable VF test results. However, some eyes whose VF POAG end point was confirmed by 3 consecutive, abnormal, reliable test results nonetheless had 1 or more normal test results on follow-up.

Author Affiliations: Visual Field Reading Center, Department of Ophthalmology, University of California, Davis, Sacramento (Dr Keltner and Ms Cello); Discoveries in Sight, Devers Eye Institute, Portland, Ore (Dr Johnson); Department of Mathematics and Statistics, San Diego State University, San Diego, Calif (Drs Levine and Fan); Department of Ophthalmology and Visual Sciences, Washington University, St Louis, Mo (Drs Kass and Gordon).
Group Information: A complete list of the members of the Ocular Hypertension Treatment Study (OHTS) Group appears on the OHTS Web site: https://vrcc.wustl.edu.

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