This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (7)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Ophthalmological Procedures, Other  • Alert me on articles by topic  Social Bookmarking   What's this?

Yong Tao, MD; Yan-Rong Jiang, MD; Xiao-Xin Li, MD; Chun-Yue Yin, MD; Jin Yao, MD

Arch Ophthalmol. 2005;123:1097-1101.

Objective  To demonstrate the fundus and histopathological changes in the normal miniature pig eye after radial optic neurotomy.

Methods  Ophthalmoscopic examinations, fundus photography, and fluorescein angiography were performed on 12 eyes that underwent radial optic neurotomy, 5 normal eyes, and 7 eyes that underwent vitrectomy (from 12 pigs in total) preoperatively and 1, 7, 14, 30, and 90 days postoperatively. These eyes were enucleated 120 days postoperatively. Sixteen eyes (of 8 pigs in total) that underwent radial optic neurotomy were enucleated 1, 3, 7, and 48 days (2 pigs each time) postoperatively. The enucleated eye sections were stained with hematoxylin-eosin, Masson trichrome, and Luxol fast blue.

Results  The retina radial to the site of radial optic neurotomy darkened gradually with the increasing curvature of the major retinal arteries. The filling time intervals from the retinal artery to the retinal vein were prolonged. At the incision site, there was a loss of nerve fibers, which were subsequently replaced by collagenous tissue. No anastomotic vessels formed by the end of the study.

Conclusions  Postoperatively, the retinal circulation seemed somewhat sluggish compared with that seen preoperatively. Segmental retinal nerve atrophy eventually formed. The procedure itself may not be the sole factor for the formation of shunt vessels.

Clinical Relevance  To date, radial optic neurotomy is controversial and persuasive animal studies are lacking. In combining fluorescein angiography with histopathological examination, this study may be somewhat helpful.

Author Affiliations: Department of Ophthalmology, People’s Hospital, Peking University, Beijing, China.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Radial Optic Neurotomy Using Nasal and Temporal Approach Incisions: Histopathologic Study in Human Cadaver Eyes
Altaweel et al.
Arch Ophthalmol 2007;125:1553-1557.
ABSTRACT | FULL TEXT