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Anastasios G. P. Konstas, MD, PhD; Kostantinos Boboridis, MD; Despina Tzetzi, MD; Kostantinos Kallinderis, MD; Jessica N. Jenkins, BS; William C. Stewart, MD

Arch Ophthalmol. 2005;123:898-902.

Objective  To evaluate the 24-hour efficacy and safety of the latanoprost-timolol maleate–fixed combination vs latanoprost therapy in patients with primary open-angle glaucoma.

Methods  A prospective, observer-masked, crossover, active-controlled, randomized comparison in which after a 6-week medicine-free period, patients were randomized to either latanoprost-timolol–fixed combination therapy or latanoprost therapy, both dosed once each evening, alone for 8 weeks. Patients were then switched to the opposite treatment for 8 weeks. At the end of the washout and treatment periods, a 24-hour diurnal curve was performed.

Results  The baseline untreated mean ± SD diurnal curve in 37 patients who completed the study was 24.2 ± 2.0 mm Hg. The mean diurnal curve was 19.2 ± 2.6 mm Hg for those who received latanoprost therapy alone and 16.7 ± 2.1 mm Hg for those who received the fixed combination therapy (P<.001). The fixed combination therapy also provided a lower absolute intraocular pressure level (1.5-2.9 mm Hg, P<.001) and a greater intraocular pressure reduction from the untreated baseline (P<.001). Stinging was statistically lower with latanoprost therapy alone (P = .04), but itching was statistically increased compared with the fixed combination therapy (P = .04).

Conclusion  The result of this study suggests that the latanoprost-timolol–fixed combination compared with latanoprost therapy alone provides improved intraocular pressure reduction over the 24-hour diurnal curve and for each individual time point in patients with primary open-angle glaucoma.

Author Affiliations: Glaucoma Unit, University Department of Ophthalmology, Australasian Hellenic Educational Progressive Association Hospital, Thessaloniki, Greece (Drs Konstas, Boboridis, Tzetzi, and Kallinderis); Pharmaceutical Research Network, LLC, Charleston, SC (Ms Jenkins and Dr Stewart); and the South Carolina Eye Institute affiliated with the University of South Carolina, Columbia (Dr Stewart).

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