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The Los Angeles Latino Eye Study

Denise R. Globe, PhD; Rohit Varma, MD, MPH; Mina Torres, MS; Joanne Wu, MPH; Ronald Klein, MD, MPH; Stanley P. Azen, PhD; for the Los Angeles Latino Eye Study Group

Arch Ophthalmol. 2005;123:815-821.

Objective  To assess the association of self-reported systemic and ocular comorbid disease and visual function in Latino subjects.

Methods  National Eye Institute 25-item Visual Function Questionnaire (NEI-VFQ-25) and eye examination data were obtained from 5380 participants in the Los Angeles Latino Eye Study, a population-based prevalence study of eye disease in Latino subjects 40 years and older. We developed and contrasted 5 comorbidity measures. One-way analysis of variance was used to assess the association between comorbidity and visual impairment and self-reported visual function. Regression analyses determined the association of sociodemographic variables, clinical variables, and the best measure of comorbidity with the NEI-VFQ-25 composite score. The main outcome measure was self-reported visual function as assessed by the NEI-VFQ-25 composite score.

Results  On average, visual function subscale scores were lowest for those participants with the most systemic comorbid conditions (P<.05). This was more evident in participants with moderate or severe visual impairment compared with those with mild or no visual impairment (P<.05).

Conclusions  Self-reported systemic comorbidities were associated with self-reported visual function. This association was greater at more severe levels of visual impairment. Of the 5 comorbidity measures assessed, the measure that summed the number of self-reported systemic comorbidities correlated most with self-reported visual function.

Author Affiliations: Department of Pharmaceutical Economics and Policy, School of Pharmacy (Dr Globe and Ms Wu), and Department of Preventive Medicine (Drs Varma and Azen and Ms Torres) and Doheny Eye Institute and Department of Ophthalmology (Drs Varma and Azen), Keck School of Medicine, University of Southern California, Los Angeles; and Ocular Epidemiology Grading Center and Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison (Dr Klein).

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