This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (12)  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal  Topic Collections  • Endophthalmitis  • Alert me on articles by topic  Social Bookmarking   What's this?

A Systematic Review

Mehran Taban, MD; Ashley Behrens, MD; Robert L. Newcomb, PhD; Matthew Y. Nobe; Peter J. McDonnell, MD

Arch Ophthalmol. 2005;123:605-609.

Objective  To determine the incidence of acute endophthalmitis following penetrating keratoplasty (PK) over time.

Methods  A systematic review of English-language articles was conducted by performing a broad search of the PubMed database from 1963 through March 2003 using such keywords as penetrating keratoplasty, endophthalmitis, and postoperative complication. Additional studies were identified from bibliographies of relevant articles and published proceedings. The proportion of eyes with acute endophthalmitis as a postoperative complication was recorded, and pooled incidence rates were assessed over time.

Results  From 1870 unique, potentially relevant citations, 66 original studies that addressed endophthalmitis and met the selection criteria were analyzed. A total of 90 549 PKs were pooled, resulting in an overall estimate of 0.382% post-PK endophthalmitis, but a change over time was noted. The rate of endophthalmitis was 0.200% in the 2000-2003 period, 0.453% in the 1990s, 0.376% in the 1980s, and 0.142% during the 1970s. Furthermore, a downward trend in the incidence of endophthalmitis after 1992 was observed compared with 1991 and earlier.

Conclusions  This systematic review indicates that the incidence of endophthalmitis associated with PK has declined during the last decade.

Author Affiliations: Departments of Ophthalmology (Dr Taban and Mr Nobe) and Statistics (Dr Newcomb), University of California at Irvine; and Wilmer Ophthalmological Institute, The Johns Hopkins University, Baltimore, Md (Drs Behrens and McDonnell).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

RELATED ARTICLE

Acute Endophthalmitis Following Cataract Surgery: A Systematic Review of the Literature
Mehran Taban, Ashley Behrens, Robert L. Newcomb, Matthew Y. Nobe, Golnaz Saedi, Paula M. Sweet, and Peter J. McDonnell
Arch Ophthalmol. 2005;123(5):613-620.
ABSTRACT | FULL TEXT  

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Infectious Disease Risk Factors of Corneal Graft Donors
Hassan et al.
Arch Ophthalmol 2008;126:235-239.
ABSTRACT | FULL TEXT  

Infectious Disease Risk Factors of Corneal Donors: Is There New Cause for Concern?
Sugar
Arch Ophthalmol 2008;126:262-262.
FULL TEXT  

From the Library
Br J Ophthalmol 2005;89:1072-1072.
FULL TEXT  

Acute Endophthalmitis Following Cataract Surgery: A Systematic Review of the Literature
Taban et al.
Arch Ophthalmol 2005;123:613-620.
ABSTRACT | FULL TEXT