This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on ISI (10)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Randomized Controlled Trial  • Glaucoma  • Alert me on articles by topic

Tin Aung, PhD, FRCS(Edin), FRCOphth; Winifred P. Nolan, MD, FRCOphth; David Machin, PhD; Steve K. L. Seah, FRCS(Edin), FRCOphth; Jamyanjav Baasanhu, MD, PhD; Peng T. Khaw, PhD, FRCOphth, FRCP, FRCPath; Gordon J. Johnson, MD, FRCS(C); Paul J. Foster, PhD, FRCS(Edin)

Arch Ophthalmol. 2005;123:527-532.

Objective  To evaluate the risk of peripheral anterior synechiae (PAS) and glaucomatous optic neuropathy attributable to primary angle closure at varying anterior chamber depths (ACDs) in two East Asian populations.

Methods  Participants 40 years and older were from 2 population-based glaucoma surveys in Mongolia and Singapore. Central ACD was measured by optical pachymetry. Presence of PAS was determined by dynamic gonioscopy. Cases with secondary PAS were excluded. Glaucomatous optic neuropathy was diagnosed in subjects with structural and functional evidence of glaucoma.

Results  A total of 2032 subjects, consisting of 942 Mongolians and 1090 Chinese Singaporeans, were included in this study. A logistic model of the relationship between ACD and PAS among Singaporeans showed a consistent, incremental increase in PAS across the entire range of ACD. In deeper anterior chambers the rate of PAS exceeded that seen in Mongolians. In Mongolians, there was a clear threshold for ACD (2.4 mm) at or above which PAS were very uncommon. With ACD less than 2.4 mm, the rate of PAS rose rapidly to overtake that seen in Singaporeans.

Conclusions  Shallow anterior chambers are a significant risk factor for angle closure in East Asians, although the nature of the association is specific to the individual population. There was a trend toward higher rates of glaucomatous optic neuropathy in people with the shallowest anterior chambers.

Author Affiliations: Institute of Ophthalmology, University College London, London, England (Drs Aung, Nolan, Khaw, Johnson, and Foster); Glaucoma Research Unit, Moorfields Eye Hospital, London (Drs Aung, Nolan, Khaw, and Foster); Singapore National Eye Centre, Singapore (Drs Aung and Seah); Division of Clinical Trials and Epidemiological Sciences, National Cancer Centre, Singapore (Dr Machin); Central Medical University, Ulaanbaatar, Mongolia (Dr Baasanhu).

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Anterior Chamber Configuration in Patients with Glaucoma: MR Gonioscopy Evaluation with Half-Fourier Single-Shot RARE Sequence and Microscopy Coil
Tanitame et al.
Radiology 2008;0:2483071556.
ABSTRACT | FULL TEXT  

Determinants of Angle Closure in Older Singaporeans
Lavanya et al.
Arch Ophthalmol 2008;126:686-691.
ABSTRACT | FULL TEXT  

Heritability of the Iridotrabecular Angle Width Measured by Optical Coherence Tomography in Chinese Children: The Guangzhou Twin Eye Study
He et al.
IOVS 2008;49:1356-1361.
ABSTRACT | FULL TEXT  

Frequency-Doubling Threshold Perimetry in Predicting Glaucoma in a Population-Based Study: The Beijing Eye Study
Wang et al.
Arch Ophthalmol 2007;125:1402-1406.
ABSTRACT | FULL TEXT  

Prevalence of glaucoma in rural Myanmar: the Meiktila Eye Study
Casson et al.
Br. J. Ophthalmol. 2007;91:710-714.
ABSTRACT | FULL TEXT