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Ultra-high Speed, Ultra-high Resolution Ophthalmic Imaging

Teresa C. Chen, MD; Barry Cense, PhD; Mark C. Pierce, PhD; Nader Nassif, BS; B. Hyle Park, PhD; Seok H. Yun, PhD; Brian R. White, BS; Brett E. Bouma, PhD; Guillermo J. Tearney, MD, PhD; Johannes F. de Boer, PhD

Arch Ophthalmol. 2005;123:1715-1720.

Objective  To introduce a new ophthalmic optical coherence tomography technology that allows unprecedented simultaneous ultra-high speed and ultra-high resolution.

Methods  Using a superluminescent diode source, a clinically viable ultra-high speed, ultra-high resolution spectral domain optical coherence tomography system was developed.

Results  In vivo images of the retina, the optic nerve head, and retinal blood flow were obtained at an ultra-high speed of 34.1 microseconds (ms) per A-scan, which is 73 times faster than commercially available optical coherence tomography instruments. Single images (B-scans) consisting of 1000 A-scans were acquired in 34.1 ms, allowing video rate imaging at 29 frames per second with an axial resolution of 6 µm. Using a different source in a slightly slower configuration, single images consisting of 500 A-scans were acquired in 34 ms, allowing imaging at 29 frames per second at an axial resolution of 3.5 µm, which is 3 times better than commercially available optical coherence tomography instruments. The amount of energy directed into the eye in both cases, 600 µW, is less than that of the Stratus OCT3 and is safe for intrabeam viewing for up to 8 hours at the same retinal location.

Conclusion  Spectral domain optical coherence tomography technology enables ophthalmic imaging with unprecedented simultaneous ultra-high speed and ultra-high resolution.

Author Affiliations: Department of Ophthalmology, Harvard Medical School, Boston, Mass (Dr Chen); Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston (Drs Cense, Pierce, Park, Yun, Bouma, Tearney, de Boer, and Messers Nassif and White).

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