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Dustin Dierks, MD; Bo Lei, PhD; Keqing Zhang, BS; Dean P. Hainsworth, MD

Arch Ophthalmol. 2005;123:1563-1569.

Objective  To investigate the clinical, histologic, and electroretinographic effects of intravitreal injection of triamcinolone acetonide suspension in the rabbit retina.

Methods  Three groups of 6 rabbits each received intravitreal injections. Group 1 received 4 mg of triamcinolone acetonide, group 2 received an equal volume (0.1 mL) of the corticosteroid supernatant, and group 3 received 4 mg of triamcinolone acetonide with the supernatant replaced with balanced salt solution. Uninjected left eyes served as controls. Electroretinograms were obtained at baseline and at 3 to 4 and 6 to 7 days after injection of triamcinolone. Enucleated eyes were examined histologically.

Results  Ocular examination revealed no differences among the 3 groups. When subjected to stimulation with moderate to high flash intensities, eyes that had received intravitreal injections of triamcinolone (groups 1 and 3) had a 10% to 25% increase in dark-adapted a- and b-wave electroretinographic amplitudes. No histologic differences were observed between injected and control eyes.

Conclusions  Intravitreal injection of 4 mg of triamcinolone acetonide does not cause a toxic reaction in the rabbit retina after 7 days. Triamcinolone therapy may augment the rod-driven electroretinographic responses, suggesting a mechanism by which visual function may improve.

Clinical Relevance  Evaluation of the toxic effects of triamcinolone is useful because of increased applications of intravitreal injection.

Author Affiliations: Mason Eye Institute (Drs Dierks, Lei, and Hainsworth) and Department of Veterinary Medicine and Surgery, College of Veterinary Medicine (Dr Lei and Mrs Zhang), University of Missouri–Columbia.

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RELATED LETTERS

Effects of Intravitreous Injection of Preserved and Nonpreserved Triamcinolone in Rabbit Retina
Petros E. Carvounis, Muhammad Abd El Barr, Thomas A. Albini, and Eric R. Holz
Arch Ophthalmol. 2006;124(11):1666.
EXTRACT | FULL TEXT  

Effects of Intravitreous Injection of Preserved and Nonpreserved Triamcinolone in Rabbit Retina—Reply
Dustin Dierks, Bo Lei, Keqing Zhang, and Dean P. Hainsworth
Arch Ophthalmol. 2006;124(11):1666-1668.
EXTRACT | FULL TEXT  

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