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Wei-Yong Shen, MD, PhD; Shu Yen Lee, MD; Ian Yeo, MD; Chooi-May Lai, PhD; Ranjana Mathur, MD; Donald Tan, PhD; Ian J. Constable, MD; P. Elizabeth Rakoczy, PhD

Arch Ophthalmol. 2004;122:353-360.

Objective  To determine the key factors for creating a high incidence model of choroidal neovascularization (CNV) in the monkey.

Methods  Intense laser photocoagulation was performed in 8 eyes of 4 monkeys using krypton red and green-yellow and Alcon frequency-doubled diode ophthalmic lasers. Eight to 13 lesions were delivered to an area between the temporal vascular arcades in each eye. Development of CNV was monitored by fluorescein angiography at 2 and 4 weeks after laser treatment, and the results were correlated with histological analysis.

Results  A much higher incidence of CNV occurred in the macular region, which refers to an anatomic area equivalent to a mean ± SD 2.5 ± 0.4 times the horizontal diameter of the optic disc in the fundus. Regardless of the type of ophthalmic laser used, 72% of lesions developed fluorescein leakage within the macula, compared with 12% outside the macula (P<.001). By histological analysis, 89% of lesions developed microscopic CNV within the macula vs 22% outside the macula (P<.001).

Conclusion  The macular region is predisposed to creation of laser-induced CNV in the monkey.

Clinical Relevance  The predilection of the macular region to a high incidence of laser-induced CNV may account for the high recurrence rate of subfoveal CNV after laser treatment in humans.

From the Department of Molecular Ophthalmology, Lions Eye Institute, and Centre for Ophthalmology and Visual Science, University of Western Australia, Nedlands (Drs Shen, Lai, Constable, and Rakoczy), and Singapore Eye Research Institute, National University of Singapore (Drs Lee, Yeo, Mathur, and Tan).

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