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CRYO-ROP Cooperative Group^*

Arch Ophthalmol. 2004;122:1659-1666.

Objective  To describe parental perspectives on health status and health-related quality of life (HRQL) at age 10 years in children with birth weights less than 1251 g who participated in the multicenter Cryotherapy for Retinopathy of Prematurity (CRYO-ROP) study.

Methods  In 244 participants in the randomized CRYO-ROP trial and 102 CRYO-ROP participants who did not develop ROP, the Health Utilities Index (HUI) system was used to characterize health status for the following 8 attributes: vision, hearing, speech, ambulation, dexterity, emotion, cognition, and pain. Using a utility formula, HRQL was determined for each child on a scale from 0.0 (dead) to 1.00 (perfect health).

Results  The proportion of the ROP-randomized group with limitations in 4 attributes or more was 20.6% compared with 2.0% for the no-ROP group. Within the ROP-randomized group, the proportion of "sighted" children with limitations in 4 attributes or more was 6.4% vs 46.5% in the "blind/low vision" group. The median HRQL score for the ROP-randomized children was lower than for the no-ROP children (0.72 vs 0.97, P<.001); the median HRQL score for the sighted-randomized children was 0.87 vs 0.27 for the blind/low vision children (P<.001).

Conclusions  Threshold ROP was associated with functional limitations in health attributes and reduction in HRQL scores at age 10 years. Furthermore, among children who developed threshold ROP, a greater reduction in HRQL scores was found among children with a poor visual outcome compared with those with better sight.

*Authors: This report was prepared on behalf of the CRYO-ROP Cooperative Group by Graham E. Quinn, MD, MSCE; Velma Dobson, PhD; Saroj Saigal, MD, FRCP; Dale L. Phelps, MD; Robert J. Hardy, PhD; Betty Tung, MS; C. Gail Summers, MD; and Earl A. Palmer, MD.
Group Information: A list of the Cryotherapy for Retinopathy of Prematurity Cooperative Group as of August 15, 2001, was published in Arch Ophthalmol. 2001;119:1110-1118.

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