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Danjie Li, MD; Masayuki Horiguchi, MD; Shoji Kishi, MD

Arch Ophthalmol. 2004;122:1462-1467.

Objective  To determine the relationship between the tomographic and electrophysiologic characteristics of the retina with an idiopathic epimacular membrane.

Methods  Sixty patients with unilateral idiopathic epimacular membranes underwent optical coherence tomography and multifocal electroretinography (mfERG). The mfERGs were elicited by a pseudorandom m-sequence stimulus with 37 hexagonal elements, and the mfERGs in area 1 (central 4.1°), area 2 (ring from 4.10°-7.15°), and area 3 (ring from 7.15°-13.75°) were compared with the tomographic features of the corresponding area. The data from the normal fellow eyes served as control.

Main Outcome Measures  The retinal thickness, amplitudes, and implicit time of the mfERG.

Results  On optical coherence tomographs, the retina was thickest in area 1, followed by area 2 with low tissue reflectivity of the outer retina, and area 3 was of normal thickness. Electroretinography showed the amplitude ratio (affected vs fellow eyes) of mfERGs from areas 1, 2, and 3 was significantly lower than that of the controls (P<.01), and the implicit times were significantly delayed (P<.01). The amplitude ratio was reduced the most in area 1, and the implicit time was delayed the most in area 3. The foveal thickness was negatively correlated with visual acuity ( = –0.46; P<.001). The mfERG amplitude in area 1 was not significantly correlated with the visual acuity.

Conclusions  It is likely that retinal thickness is correlated with neural dysfunction, but mfERGs demonstrated various physiological changes in the retina.

From the Department of Ophthalmology, Gunma University School of Medicine, Maebashi, Gunma, Japan (Drs Li and Kishi); and the Department of Ophthalmology, Fujita-Health University, School of Medcine, Toyoake, Aichi, Japan (Dr Horiguchi).The authors have no relevant financial interest in this article.

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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

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Arch Ophthalmol 2007;125:1194-1200.
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