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Factors Associated With Long-term Progression or Stability in Exfoliation Glaucoma
Anastasios G. P. Konstas, MD, PhD;
Gabor Hollo, MD, PhD;
Yuri S. Astakhov, MD, PhD;
Miguel A. Teus, MD, PhD;
Evgeny L. Akopov, MD;
Jessica N. Jenkins, BS;
William C. Stewart, MD
Arch Ophthalmol. 2004;122:29-33.
Objective To evaluate the effect of intraocular pressure (IOP) reduction on long-term progression or stability in patients with exfoliation glaucoma.
Design Multicenter (Greece, Spain, Russia, and Hungary), retrospective analysis.
Methods Medical record analysis of 167 patients with at least 5 years of follow-up, who were stable (n = 85) or whose condition had progressed (n = 82) after the beginning of the follow-up period.
Results The mean ± SD IOP was 18.1 ± 2.6 mm Hg in the stable group and 20.1 ± 4.3 mm Hg in the progressed group (P<.001). The mean ± SD follow-up time was 6.1 ± 2.3 years for the stable group and 3.4 ± 1.7 years for the progressed group. The mean SD for each patient's average IOP was 2.9 mm Hg for the stable group and 4.6 mm Hg for the progressed group (P<.001). Twenty-eight percent of patients who had a mean IOP of 17 mm Hg or lower, 43% of those with an IOP of 18 to 19 mm Hg, and 70% of those with an IOP of 20 mm Hg or higher progressed. Progressed patients had statistically greater optic disc damage at baseline and more medication changes and trabeculectomies during follow-up than stable patients (P<.05).
Conclusion This study suggests that IOP reduction helps to prevent glaucoma progression in patients with exfoliation glaucoma, although it does not guarantee the prevention or worsening of the disease.
From the University Department of Ophthalmology, AHEPA Hospital, Thessaloniki, Greece (Dr Konstas); Department of Ophthalmology, Semmelweis University, Budapest, Hungary (Dr Hollo); University Department of Ophthalmology, Saint Petersburg, Russia (Drs Astakhov and Akopov); Hospital Oftalmologico International de Madrid, Madrid, Spain (Dr Teus); Pharmaceutical Research Network, LLC, Charleston, SC (Ms Jenkins and Dr Stewart); and Department of Ophthalmology, University of South Carolina, Columbia (Dr Stewart)
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