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Prognostic Value of S-100- Serum Concentration in Patients With Uveal Melanoma

Guy S. O. A. Missotten, MD; Nancy E. M. L. Tang, MD; Catharina M. Korse; H. Monique H. Hurks; Didi de Wolff-Rouendaal, MD; Jan E. E. Keunen, MD; Martine J. Jager, MD; Johannes M. G. Bonfrer, MD

Arch Ophthalmol. 2003;121:1117-1119.

Background  In cutaneous melanoma, the S-100- serum level is recognized as a marker of metastatic disease.

Objectives  To determine whether S-100- is present in the serum of patients with uveal melanoma and to test whether the serum concentration of S-100- is related to known clinical and histopathological prognostic factors in these patients.

Methods  The S-100- concentration was measured in serum samples collected from 64 patients with uveal melanoma before enucleation and from 58 healthy control subjects. A 2-site immunoluminometric assay was used to quantify the S-100- concentration in serum. S-100- concentrations in the serum from patients were compared with clinicopathological tumor variables, sex, occurrence of metastasis, and survival.

Results  Thirty-seven (57.8%) of 64 patients with uveal melanoma showed detectable levels of serum S-100-. There was, however, no significant difference between serum levels of patients and control subjects (P = .71). Statistical analysis showed no significant correlation between S-100- concentration and any of the clinicopathological tumor variables, occurrence of metastases, or survival. Only sex was correlated with S-100- serum levels, which was not observed in the control group.

Conclusions  In our study on patients with uveal melanoma, the S-100- serum concentration was not correlated with any investigated prognostic factor and was not of prognostic value itself. Female patients appeared to have higher S-100- concentrations than male patients.

From the Department of Ophthalmology, Leiden University Medical Center, Leiden (Drs Missotten, Tang, Wolff-Rouendaal, Keunen, and Jager and Ms Hurks), and the Netherlands Cancer Institute, Amsterdam (Ms Korse and Dr Bonfrer), the Netherlands. The authors have no relevant financial interest in this article.

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