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The Pediatric Eye Disease Investigator Group*

Arch Ophthalmol. 2003;121:603-611.

Objective  To compare 2 hours vs 6 hours of daily patching as treatments for moderate amblyopia in children younger than 7 years.

Methods  In a randomized multicenter (35 sites) clinical trial, 189 children younger than 7 years with amblyopia in the range of 20/40 to 20/80 were assigned to receive either 2 hours or 6 hours of daily patching combined with at least 1 hour per day of near visual activities during patching.

Main Outcome Measure  Visual acuity in the amblyopic eye after 4 months.

Results  Visual acuity in the amblyopic eye improved a similar amount in both groups. The improvement in the visual acuity of the amblyopic eye from baseline to 4 months averaged 2.40 lines in each group (P = .98). The 4-month visual acuity was at least 20/32 and/or improved from baseline by 3 or more lines in 62% of patients in each group (P>.99).

Conclusion  When combined with prescribing 1 hour of near visual activities, 2 hours of daily patching produces an improvement in visual acuity that is of similar magnitude to the improvement produced by 6 hours of daily patching in treating moderate amblyopia in children aged 3 to 7 years.

*The Writing Committee served as author for the Pediatric Eye Disease Investigator Group (PEDIG). The Coordinating Center is located at the Jaeb Center for Health Research, Tampa, Fla. The members of PEDIG have no relevant financial interest in this article.

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