 |
|
The Effect of Latanoprost, Brimonidine, and a Fixed Combination of Timolol and Dorzolamide on Circadian Intraocular Pressure in Patients With Glaucoma or Ocular Hypertension
Nicola Orzalesi, MD;
Luca Rossetti, MD;
Andrea Bottoli, MD;
Elena Fumagalli, MD;
Paolo Fogagnolo, MD
Arch Ophthalmol. 2003;121:453-457.
Objective To compare the circadian intraocular pressure (IOP) reductions induced by latanoprost, brimonidine tartrate, and a fixed combination of timolol maleate and dorzolamide hydrochloride in patients with primary open-angle glaucoma (POAG) or ocular hypertension (OHT).
Methods In this crossover study, 10 patients with POAG and 10 with OHT were treated with latanoprost once a day, brimonidine twice a day, and a fixed combination of timolol and dorzolamide twice a day for 1 month. Four 24-hour tonometric curves were obtained for each patient. Intraocular pressure (IOP) was measured at 3, 6, and 9 AM, and at noon and at 3, 6, and 9 PM, and at midnight, using a handheld electronic tonometer with the patient in supine and sitting positions and a Goldmann applanation tonometer with the patient sitting at the slitlamp.
Main Outcome Measure Reduction of circadian IOP.
Results All the drugs significantly reduced IOP compared with the baseline at all times, except for brimonidine at midnight, 3 AM, and 6 AM. Latanoprost was more effective than brimonidine in lowering IOP at 3 and 6 AM and at 3 PM (P = .03), and the combination of timolol and dorzolamide was more effective than brimonidine at 3 and 9 AM (P = .04) and at 3 and 6 PM (P = .05) and more effective than latanoprost at 9 AM (P = .05).
Conclusion Latanoprost and the fixed combination of timolol and dorzolamide led to similar circadian reductions in IOP, whereas brimonidine was less effective, particularly during the night.
From the Eye Clinic, Institute of Biomedical Sciences, University of Milan, San Paolo Hospital, Milan, Italy. The authors have no relevant financial interest in this article.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Effects of the Timolol-Dorzolamide Fixed Combination and Latanoprost on Circadian Diastolic Ocular Perfusion Pressure in Glaucoma
Quaranta et al.
IOVS 2008;49:4226-4231.
ABSTRACT
| FULL TEXT
Effect on Diurnal Intraocular Pressure Variation of Eliminating the {alpha}-2 Adrenergic Receptor Subtypes in the Mouse
Aihara et al.
IOVS 2008;49:929-933.
ABSTRACT
| FULL TEXT
Quality of diurnal intraocular pressure control in primary open-angle patients treated with latanoprost compared with surgically treated glaucoma patients: a prospective trial
Mansouri et al.
Br. J. Ophthalmol. 2008;92:332-336.
ABSTRACT
| FULL TEXT
Meta-analysis of randomised controlled trials comparing latanoprost with brimonidine in the treatment of open-angle glaucoma, ocular hypertension or normal-tension glaucoma
Fung et al.
Br. J. Ophthalmol. 2007;91:62-68.
ABSTRACT
| FULL TEXT
24-Hour Control With a Latanoprost-Timolol Fixed Combination vs Timolol Alone.
Konstas et al.
Arch Ophthalmol 2006;124:1553-1557.
ABSTRACT
| FULL TEXT
Effects of Topical Hypotensive Drugs on Circadian IOP, Blood Pressure, and Calculated Diastolic Ocular Perfusion Pressure in Patients with Glaucoma.
Quaranta et al.
IOVS 2006;47:2917-2923.
ABSTRACT
| FULL TEXT
Clinical utility of intraocular pressure monitoring outside of normal office hours in patients with glaucoma.
Barkana et al.
Arch Ophthalmol 2006;124:793-797.
ABSTRACT
| FULL TEXT
Circadian variations in central corneal thickness and intraocular pressure in patients with glaucoma
Fogagnolo et al.
Br. J. Ophthalmol. 2006;90:24-28.
ABSTRACT
| FULL TEXT
Twenty-four-Hour Control With Latanoprost-Timolol-Fixed Combination Therapy vs Latanoprost Therapy
Konstas et al.
Arch Ophthalmol 2005;123:898-902.
ABSTRACT
| FULL TEXT
|
