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Retinochoroidal Collateral Veins Protect Against Anterior Segment Neovascularization After Central Retinal Vein Occlusion
Jeffrey J. Fuller, MD;
John O. Mason, III, MD;
Milton F. White, Jr, MD;
Gerald McGwin, Jr, MS, PhD;
Tracy L. Emond, COT;
Richard M. Feist, MD
Arch Ophthalmol. 2003;121:332-336.
Objective To test the hypothesis that retinochoroidal collateral veins (RCVs), or alternatively, retinociliary or optociliary shunts/collaterals/veins or opticociliary anastomoses, act protectively against the development of anterior segment neovascularization (ASN) following central retinal vein occlusion (CRVO).
Design Case-control retrospective medical record review of patients with CRVO.
Patients We identified 107 patients with CRVO, of whom 34 had developed ASN, by reviewing their medical records. After applying exclusion criteria, a case group and an age-, sex-, and visual acuity–matched control group were selected. We analyzed these groups for the presence or absence of RCVs and noted the time course involved in their development.
Main Outcome Measures Anterior segment neovascularization (including neovascularization of the iris and/or anterior chamber angle), neovascular glaucoma, and RCV development.
Results Only 1 (5.4%) of 19 individuals who developed ASN did so in the presence of RCVs. In contrast, 11 (57.9%) of 19 individuals in the control group developed RCVs. Statistical analysis revealed that patients who developed ASN were roughly 25 times less likely to have had RCVs than individuals who never developed ASN (odds ratio = 24.74; P = .001).
Conclusion Retinochoroidal collateral veins are negatively associated with ASN post-CRVO and may function in a protective manner against such an outcome.
From the Medical College of Georgia, Augusta (Dr Fuller); Retina Consultants of Alabama, Birmingham (Drs Mason, White, and Feist and Ms Emond); Department of Ophthalmology, University of Alabama at Birmingham (Drs McGwin, Mason, White, and Feist); and Callahan Eye Foundation Hospital, Birmingham (Drs Mason, White, and Feist and Ms Emond). Drs Fuller, Mason, White, McGwin, and Feist and Ms Emond have no revelant financial interest in this article.
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