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AREDS Report No. 10

Traci E. Clemons, PhD; Emily Y. Chew, MD; Susan B. Bressler, MD; Wendy McBee, MA; for the AREDS Research Group

Arch Ophthalmol. 2003;121:211-217.

Objectives  To describe the vision-targeted, health-related quality of life, measured with the National Eye Institute Visual Function Questionnaire (NEI-VFQ), in patients with age-related macular degeneration, cataract, or reduced visual acuity; to determine the relationship between the NEI-VFQ subscale scores and clinical measures of visual function; and to assess the internal consistency and reliability of the NEI-VFQ subscales.

Design  The 39-item NEI-VFQ was administered at the 5-year clinic visit to 4077 Age-Related Eye Disease Study participants.

Results  The subscales of the NEI-VFQ had moderate to high internal consistency (Cronbach's = 0.58-0.91). The NEI-VFQ scores for participants with advanced age-related macular degeneration in 1 or both eyes, severe nuclear opacity, reduced visual acuity, or cataract surgery generally were lower than scores for disease-free participants (P<.001).

Conclusion  These findings support the use of the NEI-VFQ as a measure of vision-targeted, health-related quality of life among patients with age-related macular degeneration, cataract, or reduced visual acuity.

From the AREDS Research Group. A complete list of the members of the AREDS Research Group was published previously (Arch Ophthalmol. 2001;119:1439-1452). Authors have no relevant financial interest in this article.

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