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Dorothy S. P. Fan, FRCS; Christopher B. O. Yu, FRCOphth; Thomas Y. H. Chiu, MRCS; Chun Yu Wong, FRCOphthHK, FRCS; Joan S. K. Ng, FRCS; Chi Pui Pang, DPhil; Dennis S. C. Lam, FRCS, FRCOphth

Arch Ophthalmol. 2003;121:1716-1721.

Objective  To compare the ocular-hypertensive and anti-inflammatory response to rimexolone (116-hydroxy-16fluoro-6methylpresdnisolone) and fluorometholone (21-deoxy-9fluoro-6methylprednisolone) therapy in children's eyes.

Methods  With parental consent, children who underwent surgical procedures for bilateral symmetric strabismus from January 18, 2000, through November 16, 2001, were recruited. One eye was randomized to receive topical 1% rimexolone while the contralateral eye received topical 0.1% fluorometholone, 4 times daily for 4 weeks.

Main Outcome Measures  Intraocular pressures and anti-inflammatory responses were the main outcome measures and were serially measured postoperatively for 8 weeks.

Results  Fifty-four children, aged from 4 to 8 years (mean [SD] age, 5.33 [1.26] years), participated in the study. Intraocular pressure increased significantly in both treatment groups compared with the preoperative values (P<.001). The mean (SD) peak intraocular pressure was significantly higher in the rimexolone-treated group, 19.7 (6.1) vs 17.6 (4.6) mm Hg (P<.001). Similarly, the mean (SD) net increase in intraocular pressure (P<.001), was also higher in the rimexolone-treated eyes, 5.9 (4.4) vs 3.9 (4.1) mm Hg (P<.001). In addition, a greater percentage of the rimexolone-treated patients had no conjunctival erythema on days 13 (11.1% vs 0.0%) and 20 (88.9% vs 55.6%) (P = .03).

Conclusions  Rimexolone seems to be a more effective anti-inflammatory agent than fluorometholone. However, unlike adults, the ocular-hypertensive effect in children treated with rimexolone was higher. It would be desirable to monitor the intraocular pressure regularly when rimexolone therapy is used in children.

From the Departments of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Kowloon (Drs Fan, Yu, Chiu, Pang, and Lam) and the Prince of Wales Hospital, Shatin, New Territory (Drs Wong, Ng, and Lam), Hong Kong. The authors have no relevant financial interest in this article.

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