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Jost B. Jonas, MD; Ingrid Kreissig, MD; Antje Söfker, MD; Robert F. Degenring, MD

Arch Ophthalmol. 2003;121:57-61.

Objective  To evaluate the clinical outcome of an intravitreal injection of triamcinolone acetonide as treatment of diffuse diabetic macular edema.

Participants  This prospective, interventional, clinical case series study included 20 patients (26 eyes) who received an intravitreal injection of 25 mg of triamcinolone acetonide for treatment of diffuse diabetic macular edema. Mean ± SD follow-up time was 6.64 ± 6.10 months. The study group was compared with a control group of 16 patients who underwent macular grid laser coagulation.

Main Outcome Measures  Visual acuity and intraocular pressure.

Results  In the study group, visual acuity improved significantly (P<.001), from 0.12 ± 0.08 at baseline to a maximum of 0.19 ± 0.14 during follow-up. Seventeen (81%) of 21 eyes with a follow-up period of more than 1 month had improved visual acuity. In the control group, visual acuity did not change significantly. In the study group, intraocular pressure increased significantly (P<.001), from 16.9 ± 2.5 mm Hg to a mean maximal value of 21.3 ± 4.7 mm Hg, and decreased significantly (P = .03) to 17.7 ± 4.7 mm Hg at the study's end.

Conclusion  Intravitreal injection of 25 mg of triamcinolone acetonide may be beneficial for improving visual acuity in patients with clinically significant diffuse diabetic macular edema.

From the Department of Ophthalmology and the Eye Hospital, Faculty for Clinical Medicine–Mannheim, Ruprecht Karls University, Heidelberg, Germany. The authors have no proprietary interest in the products or companies mentioned in this article.

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