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Intravascular Drug Delivery With a Pulsed Liquid Microjet
Daniel A. Fletcher, PhD;
Daniel V. Palanker, PhD;
Philip Huie, MD;
Jason Miller, MS;
Michael F. Marmor, MD;
Mark S. Blumenkranz, MD
Arch Ophthalmol. 2002;120:1206-1208.
ABSTRACT
Occlusions of the retinal veins and arteries, associated with diseases
such as hypertension and arteriosclerosis, are a major cause of severe and
irreversible loss of vision. Treatments for retinal vascular diseases have
been unsatisfactory owing in part to the difficulty of delivering drugs to
the site of disease within the eye. In this article, we demonstrate that a
new device, the vapor bubble–driven pulsed liquid microjet, can deliver
drugs into the lumen of small vessels such as those found in the retina. A
15-µm-diameter liquid jet traveling at more than 60 m/s was shown to
penetrate and deliver fluid through the wall of a blood vessel that was 60
µm in diameter. Perforation of the wall of the blood vessel did not
extend beyond the jet diameter.
From the Hansen Experimental Physics Laboratory (Drs Fletcher, Palanker,
and Huie) and the Department of Ophthalmology, School of Medicine (Drs Palanker,
Huie, Marmor, and Blumenkranz and Mr Miller), Stanford University, Stanford,
Calif. Dr Fletcher is now with the Department of Bioengineering, University
of California, Berkeley. Stanford University has applied for a patent on the
pulsed liquid microjet used in this study. The inventors are Drs Fletcher
and Palanker.
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