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Ocular Toxoplasmosis
A 50th Anniversary Tribute to the Contributions of Helenor Campbell Wilder Foerster
Gary N. Holland, MD;
Kevan G. Lewis, MS;
G. Richard O'Connor, MD
Arch Ophthalmol. 2002;120:1081-1084.
In 1952, Helenor Campbell Wilder (later Helenor Campbell Wilder Foerster)
confirmed the growing suspicion that Toxoplasma gondii
was a cause of uveitis in otherwise healthy adults by identifying the presence
of parasites in eyes enucleated because of severe intraocular inflammation.
Ocular toxoplasmosis was previously known to occur only in newborns with congenital T gondii infection. Her report ushered in a new era in
the field of uveitis in which toxoplasmosis, rather than tuberculosis, was
confirmed to be the most common cause of retinochoroiditis. Fifty years later,
issues raised in her landmark publication are still being investigated.
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From the Ocular Inflammatory Disease Center, Jules Stein Eye Institute,
and Department of Ophthalmology, University of California, Los Angeles, UCLA
School of Medicine, Los Angeles, Calif (Dr Holland and Mr Lewis); and the
Francis I. Proctor Foundation for Research in Ophthalmology and Department
of Ophthalmology, University of California, San Francisco, School of Medicine,
San Francisco (Dr O'Connor).
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