You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 120 No. 7, July 2002 TABLE OF CONTENTS
  Archives
  •  Online Features
  Laboratory Sciences
 This Article
 •Full text
 •PDF
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on ISI (3)
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal
 Topic Collections
 •Ophthalmology, Other
 •Alert me on articles by topic

Effects of Topical Anti-inflammatory and Antiallergic Eyedrops on Prostaglandin E2–Induced Aqueous Flare Elevation in Pigmented Rabbits

Yoriko Hayasaka, MD; Seiji Hayasaka, MD; Xue-Yun Zhang, PhD; Yasunori Nagaki, MD

Arch Ophthalmol. 2002;120:950-953.

Objective  To evaluate the role of topical instillation of anti-inflammatory or antiallergic agents on experimental elevation of aqueous flare induced by prostaglandin E2 (PGE2) in pigmented rabbits.

Methods  Transcorneal diffusion of PGE2, 25 µg/mL (7.09 x 10 -2mmol/L), by means of a glass cylinder produced aqueous flare elevation. Anti-inflammatory or antiallergic agents were topically administered once or twice before PGE2 application. Aqueous flare was measured with a laser flare-cell meter. Results are given as mean ± SD.

Results  Double instillations of 0.1% betamethasone sodium phosphate and 0.1% fluorometholone acetate at 4 and 2 hours before PGE2 application inhibited 61% ± 11% and 46% ± 14%, respectively, of flare elevation. Double instillations of 0.1% diclofenac sodium and 0.1% pranoprofen at 4 and 2 hours before PGE2 application did not inhibit flare elevation. Double instillations of 0.1% betamethasone, 0.1% fluorometholone, 0.1% diclofenac, and 0.1% pranoprofen at 1 and 0.5 hour before PGE2 application inhibited 16% ± 10%, 16% ± 6%, 24% ± 9%, and 23% ± 10%, respectively, of flare elevation. Double instillations of 2% cromolyn sodium, 0.5% tranilast, 0.025% levocabastine hydrochloride, 0.1% pemirolast potassium, and 0.01% ibudilast at 1 and 0.5 hour before PGE2 application did not inhibit flare elevation. Single instillation of 0.1% betamethasone 6 hours before PGE2 application inhibited 88% of PGE2-induced aqueous flare elevation. Single instillation of 0.1% diclofenac 1 hour before PGE2 application inhibited 23% of PGE2-induced aqueous flare elevation.

Conclusions  Betamethasone needed several hours after topical instillation to inhibit flare elevation, but diclofenac needed 1 hour. Antiallergic agents did not affect disruption of the blood-aqueous barrier in rabbits.

Clinical Relevance  Corticosteroid eyedrops may need several hours from instillation to show action.


From the Department of Ophthalmology, Toyama Medical and Pharmaceutical University, Toyama, Japan.







HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 2002 American Medical Association. All Rights Reserved.