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Leopard-Spot Pattern of Yellowish Subretinal Deposits in Central Serous Chorioretinopathy
Tomohiro Iida, MD;
Richard F. Spaide, MD;
Anton Haas, MD;
Lawrence A. Yannuzzi, MD;
Lee M. Jampol, MD;
Robert L. Lesser, MD
Arch Ophthalmol. 2002;120:37-42.
Objective To describe clinical and angiographic features of patients with central
serous chorioretinopathy (CSC) who had yellowish subretinal deposits forming
a reticulated leopard-spot pattern during fluorescein angiography.
Methods We conducted case studies using the clinical and photographic records
of 5 patients.
Results All 5 patients were older men between the ages of 68 and 81 years who
had been treated with corticosteroids and had bilateral CSC. Nine eyes of
the 5 patients developed yellowish deposits in a reticulated pattern in the
macular region under the chronic detached neurosensory retina. The pattern
of leopard-spot deposits was well demonstrated on the fluorescein angiogram,
with hypofluorescence in most of the deposits and hyperfluorescence from atrophy
of the retinal pigment epithelium. Later phases of the fluorescein angiographic
study showed leaks from the retinal pigment epithelium. During the indocyanine
green angiography evaluation of 4 patients, all had bilateral multifocal patches
of hyperfluorescence in the midphase, findings typical of CSC.
Conclusions Yellowish deposits forming a reticulated leopard-spot pattern may occur
under the neurosensory retina and are associated with chronic neurosensory
detachment caused by CSC. All patients were older men being treated with corticosteroids.
This report described a newly recognized finding: the subretinal deposition
of a yellowish material in a leopard-spot pattern in eyes with CSC.
From the LuEsther T. Mertz Retinal Research Center, Manhattan Eye,
Ear and Throat Hospital, and the Vitreous-Retina-Macula Consultants of New
York, New York, NY (Drs Iida, Spaide, Haas, and Yannuzzi); the Department
of Ophthalmology, Northwestern University Medical School, Chicago, Ill (Dr
Jampol); and the Department of Ophthalmology and Visual Science, Yale University
School of Medicine, New Haven, Conn (Dr Lesser). The authors have no
financial interest in any device or medication discussed in this article.
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