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  Vol. 120 No. 1, January 2002 TABLE OF CONTENTS
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Leopard-Spot Pattern of Yellowish Subretinal Deposits in Central Serous Chorioretinopathy

Tomohiro Iida, MD; Richard F. Spaide, MD; Anton Haas, MD; Lawrence A. Yannuzzi, MD; Lee M. Jampol, MD; Robert L. Lesser, MD

Arch Ophthalmol. 2002;120:37-42.

Objective  To describe clinical and angiographic features of patients with central serous chorioretinopathy (CSC) who had yellowish subretinal deposits forming a reticulated leopard-spot pattern during fluorescein angiography.

Methods  We conducted case studies using the clinical and photographic records of 5 patients.

Results  All 5 patients were older men between the ages of 68 and 81 years who had been treated with corticosteroids and had bilateral CSC. Nine eyes of the 5 patients developed yellowish deposits in a reticulated pattern in the macular region under the chronic detached neurosensory retina. The pattern of leopard-spot deposits was well demonstrated on the fluorescein angiogram, with hypofluorescence in most of the deposits and hyperfluorescence from atrophy of the retinal pigment epithelium. Later phases of the fluorescein angiographic study showed leaks from the retinal pigment epithelium. During the indocyanine green angiography evaluation of 4 patients, all had bilateral multifocal patches of hyperfluorescence in the midphase, findings typical of CSC.

Conclusions  Yellowish deposits forming a reticulated leopard-spot pattern may occur under the neurosensory retina and are associated with chronic neurosensory detachment caused by CSC. All patients were older men being treated with corticosteroids. This report described a newly recognized finding: the subretinal deposition of a yellowish material in a leopard-spot pattern in eyes with CSC.


From the LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, and the Vitreous-Retina-Macula Consultants of New York, New York, NY (Drs Iida, Spaide, Haas, and Yannuzzi); the Department of Ophthalmology, Northwestern University Medical School, Chicago, Ill (Dr Jampol); and the Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Conn (Dr Lesser).
The authors have no financial interest in any device or medication discussed in this article.


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