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Retinal Pigment Epithelial Dysfunction in Patients With Pigment Dispersion Syndrome
Implications for the Theory of Pathogenesis
Vivienne C. Greenstein, PhD;
William Seiple, PhD;
Jeffrey Liebmann, MD;
Robert Ritch, MD
Arch Ophthalmol. 2001;119:1291-1295.
Objective To test the hypothesis that the retinal pigment epithelial/photoreceptor
complex is affected in patients with pigment dispersion syndrome and/or in
patients with pigmentary glaucoma.
Methods Electro-oculograms were recorded from patients with pigment dispersion
syndrome, pigmentary glaucoma, ocular hypertension, and primary open-angle
glaucoma and from control subjects. Electro-oculograms were recorded during
15 minutes of dark adaptation followed by 15 minutes of light adaptation.
For each subject, dark-trough amplitudes, dark-trough latencies, light-peak
amplitudes, light-peak latencies, and ratios of the light-peak amplitude to
the dark-trough amplitude (Arden ratios) were calculated.
Results A 1-way analysis of variance of the Arden ratios indicated significant
differences among the groups of subjects. Results of a post hoc Newman-Keuls
test revealed that the mean Arden ratios of patients with pigment dispersion
syndrome and patients with pigmentary glaucoma were significantly lower than
the mean ratios of the controls, the patients with primary open-angle glaucoma,
and those with ocular hypertension.
Conclusions The results provide support for the hypothesis that the integrity of
the retinal pigment epithelial/photoreceptor complex is affected in patients
with pigment dispersion syndrome and in those with pigmentary glaucoma. Congenital
and/or structural abnormalities of the retinal pigment epithelial/photoreceptor
complex should be considered when models of the etiology of pigment dispersion
syndrome are proposed.
From the Departments of Ophthalmology, New York University School of
Medicine (Drs Greenstein and Seiple) and The New York Eye and Ear Infirmary
(Drs Liebmann and Ritch), New York, and The New York Medical College, Valhalla
(Drs Liebmann and Ritch).
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