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Juan M. Romero, MD; Paul T. Finger, MD; Richard B. Rosen, MD; Raymond Iezzi, MD

Arch Ophthalmol. 2001;119:1275-1282.

Objective  To evaluate the reliability of 3-dimensional ultrasound (3D-US) for the measurement of choroidal melanomas.

Design  Retrospective case series.

Participants  Forty-two consecutive cases of choroidal melanoma imaged with 3D-US.

Methods  Tumor measurements obtained with ophthalmoscopy, transillumination, standard ultrasound techniques, 3D-US, and pathological studies. Tumor diameters, heights, and volumes were compared. Our 3D-US tumor measurement techniques were tested for intraobserver and interscan reproducibility.

Results  Fifty 3D-US images were studied. The 3D-US tumor measurements were found to be reproducible (height coefficient of variation [CV] 3%; diameter CV 9.7%; volume CV 13.2%). There was significant correlation with the usual methods of tumor measurement (diameter r = 0.76; height r0.98). Significant differences were found between measurements at pathological examination, as compared with both 2-dimensional and 3D-US height measurements (range, 0.73-0.83 mm). This finding was thought to be due to specimen shrinkage. Three-dimensional ultrasound was found to be at least as reproducible as clinical examination and standard ultrasound techniques used for measurement of diameter and height of choroidal melanomas. It was our impression that the 3D-US volume measurements accounted for the geometry of the tumor better than volume estimates calculated from basal area and tumor height.

Conclusions  Three-dimensional ultrasound measurements of choroidal melanoma were reproducible, correlated well with other tumor measurement techniques, and can be used for measurement of choroidal melanomas.

From the New York Eye and Ear Infirmary (Drs Romero, Finger, Rosen, and Iezzi), and the New York Eye Cancer Center (Drs Romero and Finger), New York, NY. The authors have no proprietary or financial interest related to this article, including the equipment used in this project.

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