This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (101)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Ocular Imaging  • Alert me on articles by topic  Social Bookmarking   What's this?

Sunita Radhakrishnan, MBBS, DO; Andrew M. Rollins, PhD; Jonathan E. Roth, BS; Siavash Yazdanfar, MS; Volker Westphal, MS; David S. Bardenstein, MD; Joseph A. Izatt, PhD

Arch Ophthalmol. 2001;119:1179-1185.

Background  Recent advances in high-speed scanning technology have enabled a new generation of optical coherence tomographic (OCT) systems to perform imaging at video rate. Here, a handheld OCT probe capable of imaging the anterior segment of the eye at high frame rates is demonstrated for the first time.

Objective  To demonstrate real-time OCT imaging of anterior segment structures.

Design  Survey of anterior segment structures in normal human subjects.

Setting  Laboratory.

Main Outcome Measures  Achieving real-time imaging of the anterior segment, satisfactory image quality, and convenience of a handheld probe.

Results  Optical coherence tomographic imaging of the anterior segment of the eyes of human subjects was performed using 1310-nm wavelength light with an image rate of 8 frames per second. Imaging trials demonstrated clear resolution of corneal epithelium and stroma, sclerocorneal junction, sclera, iris pigment epithelium and stroma, and anterior lens capsule. The anterior chamber angle was clearly visualized. Limited imaging of the ciliary body was performed. Real-time imaging of pupillary constriction in response to light stimulus was also performed.

Conclusion  High-speed OCT at 1310-nm wavelength is a potentially useful technique for noninvasive assessment of anterior segment structures.

Clinical Relevance  Our results suggest that real-time OCT has potential applications in glaucoma evaluation and refractive surgery.

From the Departments of Medicine (Drs Radhakrishnan and Rollins), Biomedical Engineering (Dr Izatt and Messrs Roth, Yazdanfar, and Westphal) and Ophthalmology and Pathology (Dr Bardenstein), Case Western Reserve University, Cleveland, Ohio.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Variation of Angle Parameters in Asians: An Anterior Segment Optical Coherence Tomography Study in a Population of Singapore Malays
Amerasinghe et al.
IOVS 2009;50:2626-2631.
ABSTRACT | FULL TEXT  

Upper and Lower Tear Menisci in the Diagnosis of Dry Eye
Shen et al.
IOVS 2009;50:2722-2726.
ABSTRACT | FULL TEXT  

Comparison of Slitlamp Optical Coherence Tomography and Scanning Peripheral Anterior Chamber Depth Analyzer to Evaluate Angle Closure in Asian Eyes
Wong et al.
Arch Ophthalmol 2009;127:599-603.
ABSTRACT | FULL TEXT  

High-Definition Optical Coherence Tomography Imaging of the Iridocorneal Angle of the Eye
Wong et al.
Arch Ophthalmol 2009;127:256-260.
ABSTRACT | FULL TEXT  

Optical Effects of Anti-TGF{beta} Treatment after Photorefractive Keratectomy in a Cat Model
Buhren et al.
IOVS 2009;50:634-643.
ABSTRACT | FULL TEXT  

A Low-Cost and Simple Imaging Technique of the Anterior and Posterior Segments: Eye Fundus, Ciliary Bodies, Iridocorneal Angle
Guyomard et al.
IOVS 2008;49:5168-5174.
ABSTRACT | FULL TEXT  

Imaging the Ocular Anterior Segment With Real-Time, Full-Range Fourier-Domain Optical Coherence Tomography
Sarunic et al.
Arch Ophthalmol 2008;126:537-542.
ABSTRACT | FULL TEXT  

Assessment of the Scleral Spur in Anterior Segment Optical Coherence Tomography Images
Sakata et al.
Arch Ophthalmol 2008;126:181-185.
ABSTRACT | FULL TEXT  

Degree of angle closure and extent of peripheral anterior synechiae: an anterior segment OCT study
Su et al.
Br J Ophthalmol 2008;92:103-107.
ABSTRACT | FULL TEXT  

Changes in anterior segment morphology in response to illumination and after laser iridotomy in Asian eyes: an anterior segment OCT study
See et al.
Br J Ophthalmol 2007;91:1485-1489.
ABSTRACT | FULL TEXT  

Reproducibility of Anterior Chamber Angle Measurements Obtained with Anterior Segment Optical Coherence Tomography
Radhakrishnan et al.
IOVS 2007;48:3683-3688.
ABSTRACT | FULL TEXT  

Comparison of anterior chamber depth measurements using the IOLMaster, scanning peripheral anterior chamber depth analyser, and anterior segment optical coherence tomography
Lavanya et al.
Br J Ophthalmol 2007;91:1023-1026.
ABSTRACT | FULL TEXT  

Optical coherence tomography of the anterior segment in secondary glaucoma with corneal opacity after penetrating keratoplasty
Memarzadeh et al.
Br J Ophthalmol 2007;91:189-192.
ABSTRACT | FULL TEXT  

Repeated measurements of dynamic tear distribution on the ocular surface after instillation of artificial tears.
Wang et al.
IOVS 2006;47:3325-3329.
ABSTRACT | FULL TEXT  

Comparison of Optical Coherence Tomography and Ultrasound Biomicroscopy for Detection of Narrow Anterior Chamber Angles
Radhakrishnan et al.
Arch Ophthalmol 2005;123:1053-1059.
ABSTRACT | FULL TEXT  

Noncontact Goniometry With Optical Coherence Tomography
Wirbelauer et al.
Arch Ophthalmol 2005;123:179-185.
ABSTRACT | FULL TEXT  

Intraoperative 2-Dimensional Optical Coherence Tomography as a New Tool for Anterior Segment Surgery
Geerling et al.
Arch Ophthalmol 2005;123:253-257.
ABSTRACT | FULL TEXT  

Noncontact Measurements of Central Corneal Epithelial and Flap Thickness after Laser In Situ Keratomileusis
Wang et al.
IOVS 2004;45:1812-1816.
ABSTRACT | FULL TEXT  

Topographical Thickness of the Epithelium and Total Cornea after Overnight Wear of Reverse-Geometry Rigid Contact Lenses for Myopia Reduction
Wang et al.
IOVS 2003;44:4742-4746.
ABSTRACT | FULL TEXT  

Precorneal and Pre- and Postlens Tear Film Thickness Measured Indirectly with Optical Coherence Tomography
Wang et al.
IOVS 2003;44:2524-2528.
ABSTRACT | FULL TEXT  

Optical Coherence Tomography: A New High-Resolution Imaging Technology to Study Cardiac Development in Chick Embryos
Yelbuz et al.
Circulation 2002;106:2771-2774.
ABSTRACT | FULL TEXT  

Transscleral Optical Coherence Tomography: A New Imaging Method for the Anterior Segment of the Eye
Hoerauf et al.
Arch Ophthalmol 2002;120:816-819.
ABSTRACT | FULL TEXT