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Sunita Radhakrishnan, MBBS, DO; Andrew M. Rollins, PhD; Jonathan E. Roth, BS; Siavash Yazdanfar, MS; Volker Westphal, MS; David S. Bardenstein, MD; Joseph A. Izatt, PhD

Arch Ophthalmol. 2001;119:1179-1185.

Background  Recent advances in high-speed scanning technology have enabled a new generation of optical coherence tomographic (OCT) systems to perform imaging at video rate. Here, a handheld OCT probe capable of imaging the anterior segment of the eye at high frame rates is demonstrated for the first time.

Objective  To demonstrate real-time OCT imaging of anterior segment structures.

Design  Survey of anterior segment structures in normal human subjects.

Setting  Laboratory.

Main Outcome Measures  Achieving real-time imaging of the anterior segment, satisfactory image quality, and convenience of a handheld probe.

Results  Optical coherence tomographic imaging of the anterior segment of the eyes of human subjects was performed using 1310-nm wavelength light with an image rate of 8 frames per second. Imaging trials demonstrated clear resolution of corneal epithelium and stroma, sclerocorneal junction, sclera, iris pigment epithelium and stroma, and anterior lens capsule. The anterior chamber angle was clearly visualized. Limited imaging of the ciliary body was performed. Real-time imaging of pupillary constriction in response to light stimulus was also performed.

Conclusion  High-speed OCT at 1310-nm wavelength is a potentially useful technique for noninvasive assessment of anterior segment structures.

Clinical Relevance  Our results suggest that real-time OCT has potential applications in glaucoma evaluation and refractive surgery.

From the Departments of Medicine (Drs Radhakrishnan and Rollins), Biomedical Engineering (Dr Izatt and Messrs Roth, Yazdanfar, and Westphal) and Ophthalmology and Pathology (Dr Bardenstein), Case Western Reserve University, Cleveland, Ohio.

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