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Harvey S. Uy, MD; Quan Dong Nguyen, MD, MSc; Jean Arbour, MD; Michel Gravel, MD; Donald J. D'Amico, MD; Frederick A. Jakobiec, MD; C. Stephen Foster, MD

Arch Ophthalmol. 2001;119:603-607.

We report the clinical course and pathologic findings in a case of intraocular sclerosing inflammatory pseudotumor in a 21-year-old man. The patient initially had a unilateral right interstitial keratitis, scleritis, uveitis, ciliary body mass, and retinal detachment. Scleral and vitreous biopsy specimens revealed an inflammatory process. The eye was eventually enucleated despite therapy with high doses of prednisone and ciprofloxacin hydrochloride. Histologic examination of the globe showed nongranulomatous, acute (neutrophils) and chronic (lymphocytes and histiocytes) inflammation with proliferation of fibrous tissue within the vitreous cavity, uvea, sclera, and contiguous orbital fibroadipose tissue. The contralateral eye later developed a similar mass that resolved following aggressive and prolonged immunosuppressive therapy with retention of 20/16 visual acuity.

From the Ocular Immunology and Uveitis Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School (Drs Uy, Nguyen, Baltatzis, and Foster), Retina Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School (Drs Arbour and D'Amico), Boston; Hospital Sacre-Coeur, Montreal, Quebec (Dr Gravel); Ocular Pathology Service, Massachusetts Eye and Ear Infirmary, (Dr Jakobiec), and Schepens Retina Foundation, Schepens Eye Research Institute (Dr Nguyen), Harvard Medical School.