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The Mainz 1 Study

N. Pfeiffer, MD; I. Grierson, PhD; H. Goldsmith, BSc; D. Hochgesand, MD; A. Winkgen-Böhres, MD; P. Appleton, PhD

Arch Ophthalmol. 2001;119:191-196.

Objective  To determine whether 3 months of topical latanoprost treatment caused proliferative or degenerative effects on the peripheral iris of patients with glaucoma.

Methods  Seventeen patients requiring filtering surgery for primary open-angle glaucoma or pseudoexfoliation glaucoma were randomized to receive topical latanoprost for 3 months (n = 8) or alternative medication (n = 9) before surgery. A trabeculectomy and a peripheral iridectomy specimen was obtained from each patient during surgery. The tissue was subjected to histological and immunohistochemical evaluation using 2 cell cycle markers: proliferating cell nuclear antigen and nuclear-associated protein (Ki-67).

Results  No degenerative or pathological changes were seen in the latanoprost-treated irides, including the one specimen in this series in which there was an eye color change. Proliferating cell nuclear antigen and nuclear-associated protein markers were negative for changes in all the test specimens.

Conclusion  Short-term treatment with latanoprost does not produce morphological changes or cellular proliferation changes in the iris.

From the Department of Ophthalmology, Mainz University, Mainz, Germany (Drs Pfeiffer, Hochgesand, and Winkgen-Böhres); and the Unit of Ophthalmology, University of Liverpool, Liverpool, England (Drs Grierson and Appleton and Ms Goldsmith).

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