This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on ISI (20)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Nutritional and Metabolic Disorders  • Lipids and Lipid Disorders  • Macular Degeneration  • Alert me on articles by topic

Arch Ophthalmol. 2001;119:1833-1838.

Objective  To evaluate the associations between dietary fat and age-related maculopathy (ARM) in persons 40 years or older who participated in the Third National Health and Nutrition Examination Survey.

Methods  We used a single, nonmydriatic, fundus photograph of 1 eye to ascertain ARM status in 7883 of 11 448 survey participants. Intake of fat was estimated from 24-hour recall, and specific sources of dietary fat were estimated from responses to food frequency questionnaires. Logistic regression was used to compute odds ratios (ORs) and 95% confidence intervals (CIs) that accounted for complex survey design, nonresponse, and potential risk factors for ARM (age, smoking, race, sex, body mass index, history of cardiovascular disease or hypertension, eye color, and sedentary lifestyle). Persons aged 40 to 79 years (n = 7405) were included in analyses for early ARM (n = 644); those 60 years or older (n = 4294) were included in analyses for late ARM (n = 53).

Results  After adjustment for age, race, eye color, and sedentary lifestyle, OR for early ARM was 1.4 (95% CI, 0.9-2.2; P for trend, .10) among persons in high vs low quintiles of total fat intake (percentage of total energy). Associations for specific types of fatty acids (as percentages of caloric intake) were in the same direction and unrelated to ARM. The OR for late ARM was 0.7 (95% CI, 0.2-2.6; P for trend, .60) in persons 60 years or older. Further adjustments for other potential confounders did not significantly affect the ORs.

Conclusion  Age-related maculopathy was not significantly associated with dietary fat in this large cross-sectional survey.

Roschelle A. Heuberger, PhD; Julie A. Mares-Perlman, PhD; Ronald Klein, MD; Barbara E. K. Klein, MD; Amy E. Millen, BS; Mari Palta, PhD
From the Departments of Ophthalmology and Visual Sciences (Drs Heuberger, Mares-Perlman, R. Klein, and B. Klein and Ms Millen) and Population Health Sciences (Dr Palta), University of Wisconsin Medical School, Madison.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Oily fish consumption, dietary docosahexaenoic acid and eicosapentaenoic acid intakes, and associations with neovascular age-related macular degeneration
Augood et al.
Am. J. Clin. Nutr. 2008;88:398-406.
ABSTRACT | FULL TEXT  

Dietary {omega}-3 Fatty Acid and Fish Intake in the Primary Prevention of Age-Related Macular Degeneration: A Systematic Review and Meta-analysis
Chong et al.
Arch Ophthalmol 2008;126:826-833.
ABSTRACT | FULL TEXT  

Homeostatic Regulation of Photoreceptor Cell Integrity: Significance of the Potent Mediator Neuroprotectin D1 Biosynthesized from Docosahexaenoic Acid The Proctor Lecture
Bazan
IOVS 2007;48:4866-4881.
FULL TEXT  

Association Between Vitamin D and Age-Related Macular Degeneration in the Third National Health and Nutrition Examination Survey, 1988 Through 1994
Parekh et al.
Arch Ophthalmol 2007;125:661-669.
ABSTRACT | FULL TEXT  

The Relationship of Dietary Lipid Intake and Age-Related Macular Degeneration in a Case-Control Study: AREDS Report No. 20
Age-Related Eye Disease Study Research Group
Arch Ophthalmol 2007;125:671-679.
ABSTRACT | FULL TEXT  

A Clinician's View of the Molecular Genetics of Age-Related Maculopathy
Gorin
Arch Ophthalmol 2007;125:21-29.
ABSTRACT | FULL TEXT  

Potential role of dietary n-3 fatty acids in the prevention of dementia and macular degeneration
Johnson and Schaefer
Am. J. Clin. Nutr. 2006;83:S1494-1498S.
ABSTRACT | FULL TEXT  

Association of Adipose and Red Blood Cell Lipids With Severity of Dominant Stargardt Macular Dystrophy (STGD3) Secondary to an ELOVL4 Mutation.
Hubbard et al.
Arch Ophthalmol 2006;124:257-263.
ABSTRACT | FULL TEXT  

Prospective Study of Dietary Fat and Risk of Cataract Extraction among US Women
Lu et al.
Am J Epidemiol 2005;161:948-959.
ABSTRACT | FULL TEXT  

Nutritional Manipulation of Primate Retinas, II: Effects of Age, n-3 Fatty Acids, Lutein, and Zeaxanthin on Retinal Pigment Epithelium
Leung et al.
IOVS 2004;45:3244-3256.
ABSTRACT | FULL TEXT  

Preventing Visual Loss From Chronic Eye Disease in Primary Care: Scientific Review
Rowe et al.
JAMA 2004;291:1487-1495.
ABSTRACT | FULL TEXT  

Progression of Age-Related Macular Degeneration: Association With Dietary Fat, Transunsaturated Fat, Nuts, and Fish Intake
Seddon et al.
Arch Ophthalmol 2003;121:1728-1737.
ABSTRACT | FULL TEXT