 |
|
Aggregation of Refractive Error and 5-Year Changes in Refractive Error Among Families in the Beaver Dam Eye Study
Arch Ophthalmol. 2001;119:1679-1685.
Objective To examine aggregation of refraction, myopia, hyperopia, and astigmatism, as well as the 5-year change in each of these measures, among adult family members.
Design Geographically defined, population-based cohort study in Beaver Dam, Wis. Participants were all 43 to 84 years of age in 1988. Family relationships among participants of the study were identified through interviews. The main outcome measures were noncycloplegic refractions. Aggregation was assessed by Pearson correlations and odds ratios (ORs) that both members of a pair were affected.
Results Age-adjusted sibling correlation of refraction was 0.37 and the OR for a sibling to be myopic was 4.18, whereas the OR for being hyperopic was 2.87 (all statistically significant, P<.05). Correlations and ORs for parent-child and cousin relationships were smaller, and those for spousal relationships were not significant. Correlations and ORs for cylinder power and astigmatism were not statistically significant for most relationships considered. There were no statistically significant correlations or ORs for changes in any measure of refractive error.
Conclusions The strong aggregation of refractive error, including myopia and hyperopia, among siblings along with weaker associations among parent-child and cousin pairs and no associations among spouses suggest a potential genetic influence on refractive error. There is no such suggestion for a genetic influence on the changes in refraction or in cylinder power and astigmatism.
Kristine E. Lee, MS;
Barbara E. K. Klein, MD;
Ronald Klein, MD;
Jason P. Fine, PhD
From the Departments of Ophthalmology and Visual Sciences (Ms Lee and Drs B. E. K. Klein and K. E. Klein) and Statistics and Biostatistics (Dr Fine), University of Wisconsin Medical School, Madison.
RELATED ARTICLE
Archives of Ophthalmology Reader's Choice: Continuing Medical Education
Arch Ophthalmol. 2001;119(11):1736-1737.
FULL TEXT
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
|
Effect of breastfeeding and sociodemographic factors on visual outcome in childhood and adolescence
Rudnicka et al.
Am. J. Clin. Nutr. 2008;87:1392-1399.
ABSTRACT
| FULL TEXT
Assessment of TGIF as a Candidate Gene for Myopia
Pertile et al.
IOVS 2008;49:49-54.
ABSTRACT
| FULL TEXT
Familial aggregation of myopia in the Tehran eye study: estimation of the sibling and parent offspring recurrence risk ratios
Fotouhi et al.
Br. J. Ophthalmol. 2007;91:1440-1444.
ABSTRACT
| FULL TEXT
Heritability and Familial Aggregation of Refractive Error in the Old Order Amish
Peet et al.
IOVS 2007;48:4002-4006.
ABSTRACT
| FULL TEXT
Ethnic Differences in the Impact of Parental Myopia: Findings from a Population-Based Study of 12-Year-Old Australian Children
Ip et al.
IOVS 2007;48:2520-2528.
ABSTRACT
| FULL TEXT
Confirmation of Linkage to Ocular Refraction on Chromosome 22q and Identification of a Novel Linkage Region on 1q
Klein et al.
Arch Ophthalmol 2007;125:80-85.
ABSTRACT
| FULL TEXT
Heritability of Refractive Error and Familial Aggregation of Myopia in an Elderly American Population
Wojciechowski et al.
IOVS 2005;46:1588-1592.
ABSTRACT
| FULL TEXT
Support for Polygenic Influences on Ocular Refractive Error
Klein et al.
IOVS 2005;46:442-446.
ABSTRACT
| FULL TEXT
Familial Aggregation of Retinal Vessel Caliber in the Beaver Dam Eye Study
Lee et al.
IOVS 2004;45:3929-3933.
ABSTRACT
| FULL TEXT
Ocular Growth and Refractive Error Development in Premature Infants without Retinopathy of Prematurity
Cook et al.
IOVS 2003;44:953-960.
ABSTRACT
| FULL TEXT
|
