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Daniel J. Plummer, PhD; Stanley P. Azen, PhD; William R. Freeman, MD

Arch Ophthalmol. 2000;118:1205-1210.

Objective  To determine the effectiveness of scanning laser entoptic perimetry as a noninvasive platform for screening for retinal damage in visually asymptomatic patients within the central 120° (diameter) of vision.

Design  A masked study comparing entoptic perimetry with fundus photographs.

Setting  The Shiley Eye Center and the AIDS Ocular Research Unit at the University of California, San Diego.

Patients  Fifty-eight patients recruited during ophthalmologic visits for treatment or follow-up of ocular disease.

Measurements  For each testing session, we compared the presence of a disturbance in the entoptic stimulus with the presence of retinal disease within the central 120° of vision, centered on the fovea.

Results  Scanning laser entoptic perimetry has a sensitivity and specificity of more than 90%, a positive predictive value of 100%, and a negative predictive value of 89% for screening retinal lesions within the central 120° diameter of vision.

Conclusion  Scanning laser entoptic perimetry may be an effective and inexpensive screening test for diagnosing retinal disease in hospitals and community clinics.

From the Shiley Eye Center, Department of Ophthalmology, School of Medicine, University of California, San Diego, La Jolla (Drs Plummer and Freeman), and Statistical Consultation and Research Center, Department of Preventive Medicine, University of Southern California, Los Angeles (Dr Azen).

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