This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on ISI (60)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Ophthalmological Disorders, Other  • Articles for Residents  • Alert me on articles by topic  Social Bookmarking   What's this?

John L. Keltner, MD; Chris A. Johnson, PhD; Jacqueline M. Quigg, BS; Kimberly E. Cello, BS; Michael A. Kass, MD; Mae O. Gordon, PhD; for the Ocular Hypertension Treatment Study Group

Arch Ophthalmol. 2000;118:1187-1194.

Objective  To determine the frequency with which visual field abnormalities observed on follow-up visual fields for patients in the Ocular Hypertension Treatment Study were confirmed on retest.

Methods  Between April 1, 1994, and March 1, 1999, 21,603 visual fields were obtained from 1637 patients in the Ocular Hypertension Treatment Study. When follow-up visual fields are outside the normal limits on the Glaucoma Hemifield Test, the Corrected Pattern Standard Deviation (P<.05), or both, subsequent follow-up visual fields are monitored to confirm the abnormality. Abnormalities are confirmed if they are again abnormal on the Glaucoma Hemifield Test, the Corrected Pattern Standard Deviation, or both; if the defect is not artifactual; and if the same index and location are involved. Reliability criteria used by the study consisted of a limit of 33% for false positives, false negatives, and fixation losses.

Results  Of the 21,603 regular follow-up visual fields, 1006 were follow-up retests performed because of an abnormality (n = 748) or unreliability (n = 258). We found that 703 (94%) of the 748 visual fields were abnormal and reliable, and 45 (6%) were abnormal and unreliable. On retesting, abnormalities were not confirmed for 604 (85.9%) of the 703 originally abnormal and reliable visual fields.

Conclusions  Most visual field abnormalities in patients in the Ocular Hypertension Treatment Study were not verified on retest. Confirmation of visual field abnormalities is essential for distinguishing reproducible visual field loss from long-term variability.

From the Visual Field Reading Center, Department of Ophthalmology, University of California, Davis, Sacramento (Dr Keltner and Mss Quigg and Cello); Discoveries in Sight, Devers Eye Institute, Portland, Ore (Dr Johnson); and the Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Mo (Drs Kass and Gordon).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Visual Function-Specific Perimetry to Identify Glaucomatous Visual Loss Using Three Different Definitions of Visual Field Abnormality
Tafreshi et al.
IOVS 2009;50:1234-1240.
ABSTRACT | FULL TEXT  

Repeatability of Automated Perimetry: A Comparison between Standard Automated Perimetry with Stimulus Size III and V, Matrix, and Motion Perimetry
Wall et al.
IOVS 2009;50:974-979.
ABSTRACT | FULL TEXT  

Ocular Hypertension Treatment Study
Higginbotham
Arch Ophthalmol 2009;127:213-215.
FULL TEXT  

Comparing Multifocal VEP and Standard Automated Perimetry in High-Risk Ocular Hypertension and Early Glaucoma
Fortune et al.
IOVS 2007;48:1173-1180.
ABSTRACT | FULL TEXT  

The role of scanning laser polarimetry using the GDx variable corneal compensator in the management of glaucoma suspects
Shaikh and Salmon
Br. J. Ophthalmol. 2006;90:1454-1457.
ABSTRACT | FULL TEXT  

Asymmetries and visual field summaries as predictors of glaucoma in the ocular hypertension treatment study.
Levine et al.
IOVS 2006;47:3896-3903.
ABSTRACT | FULL TEXT  

Automated Combined Kinetic and Static Perimetry: An Alternative to Standard Perimetry in Patients With Neuro-ophthalmic Disease and Glaucoma.
Pineles et al.
Arch Ophthalmol 2006;124:363-369.
ABSTRACT | FULL TEXT  

Validation of a Predictive Model to Estimate the Risk of Conversion From Ocular Hypertension to Glaucoma
Medeiros et al.
Arch Ophthalmol 2005;123:1351-1360.
ABSTRACT | FULL TEXT  

Normal Visual Field Test Results Following Glaucomatous Visual Field End Points in the Ocular Hypertension Treatment Study
Keltner et al.
Arch Ophthalmol 2005;123:1201-1206.
ABSTRACT | FULL TEXT  

Threshold and Variability Properties of Matrix Frequency-Doubling Technology and Standard Automated Perimetry in Glaucoma
Artes et al.
IOVS 2005;46:2451-2457.
ABSTRACT | FULL TEXT  

The Ocular Hypertension Treatment Study: Topical Medication Delays or Prevents Primary Open-angle Glaucoma in African American Individuals
Higginbotham et al.
Arch Ophthalmol 2004;122:813-820.
ABSTRACT | FULL TEXT  

The Relationship between Standard Automated Perimetry and GDx VCC Measurements
Reus and Lemij
IOVS 2004;45:840-845.
ABSTRACT | FULL TEXT  

The Ocular Hypertension Treatment Study: Intraocular Pressure Lowering Prevents the Development of Glaucoma, but Does That Mean We Should Treat Before the Onset of Disease?
Robin et al.
Arch Ophthalmol 2004;122:376-378.
FULL TEXT  

Racial Differences in Optic Disc Topography: Baseline Results From the Confocal Scanning Laser Ophthalmoscopy Ancillary Study to the Ocular Hypertension Treatment Study
Zangwill et al.
Arch Ophthalmol 2004;122:22-28.
ABSTRACT | FULL TEXT  

Classification of Visual Field Abnormalities in the Ocular Hypertension Treatment Study
Keltner et al.
Arch Ophthalmol 2003;121:643-650.
ABSTRACT | FULL TEXT  

Increased Detection Rate of Glaucomatous Visual Field Damage With Locally Condensed Grids: A Comparison Between Fundus-Oriented Perimetry and Conventional Visual Field Examination
Schiefer et al.
Arch Ophthalmol 2003;121:458-465.
ABSTRACT | FULL TEXT  

Comparison of Glaucomatous Visual Field Defects Using Standard Full Threshold and Swedish Interactive Threshold Algorithms
Budenz et al.
Arch Ophthalmol 2002;120:1136-1141.
ABSTRACT | FULL TEXT  

Using Machine Learning Classifiers to Identify Glaucomatous Change Earlier in Standard Visual Fields
Sample et al.
IOVS 2002;43:2660-2665.
ABSTRACT | FULL TEXT  

The Ocular Hypertension Treatment Study: A Randomized Trial Determines That Topical Ocular Hypotensive Medication Delays or Prevents the Onset of Primary Open-Angle Glaucoma
Kass et al.
Arch Ophthalmol 2002;120:701-713.
ABSTRACT | FULL TEXT  

"Who's on First?": Considering the Options for Primary Glaucoma Therapy
Higginbotham
Arch Ophthalmol 2002;120:191-193.
FULL TEXT  

Optic Disc and Visual Field Changes in a Prospective Longitudinal Study of Patients With Glaucoma: Comparison of Scanning Laser Tomography With Conventional Perimetry and Optic Disc Photography
Chauhan et al.
Arch Ophthalmol 2001;119:1492-1499.
ABSTRACT | FULL TEXT  

Correlation of Optic Nerve Head Tomography with Visual Field Sensitivity in Papilledema
Salgarello et al.
IOVS 2001;42:1487-1494.
ABSTRACT | FULL TEXT