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Aqueous and Serum Interferon  , Interleukin (IL) 2, IL-4, and IL-10 in Patients With Uveitis
Manuel Santos Lacomba, MD;
Carmen Marcos Martin, MD;
Rafael Ramírez Chamond, MD;
Jose Maria Gallardo Galera, MD;
Mohamed Omar, MD;
Eduardo Collantes Estevez, MD
Arch Ophthalmol. 2000;118:768-772.
Objective To determine the cytokine profile in aqueous humor and peripheral blood from patients with uveitis.
Methods Cytokines (interferon [IFN]– , interleukin [IL] 2, IL-4, and IL-10) were measured in aqueous humor and peripheral blood samples from 23 patients with uveitis and 16 patients undergoing operation for uncomplicated cataracts (control group) by means of an enzyme-linked immunosorbent assay.
Results Aqueous and serum samples from patients with uveitis showed higher levels of IFN- and IL-2 than those of controls (P<.001). Similarly, serum IL-10 levels were slightly higher in the uveitis group (P=.002). No differences were found between uveitis and control groups for aqueous and serum IL-4 or aqueous IL-10 levels. In patients with uveitis, IFN- levels were significantly higher in serum than aqueous (P<.001), whereas IL-2 levels were higher in aqueous than in serum (P<.001). Serum IFN- levels correlated with severe visual damage (r=0.44; P=.03).
Conclusions Aqueous and serum levels of IFN- and IL-2 were elevated in patients with uveitis, suggesting a predominantly type 1 response (high IFN- and low IL-4 levels). Elevated serum IFN- level seems to predispose the patient to more serious loss of vision.
From the Departments of Ophthalmology (Drs Santos, Marcos, and Gallardo), Experimental Medicine (Dr Ramírez), and Rheumatology (Dr Collantes), Reina Sofia University Clinic, Córdoba, and the Department of Internal Medicine, Ciudad de Jaén Hospital, Jaén (Dr Omar), Spain. The authors have no proprietary interest in any of the products mentioned herein.
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