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Wayne Smith, BMed, BMath, MPH, PhD, FAFPHM; Paul Mitchell, MD, FRACO, FRCOphth; Stephen R. Leeder, MB, BS, PhD

Arch Ophthalmol. 2000;118:401-404.

Objective  To assess whether dietary intake of fat or fish is associated with age-related maculopathy (ARM) prevalence.

Design  Cross-sectional, urban population–based study.

Participants  People (N = 3654) aged 49 years or older.

Main Outcome Measures  Subjects with ARM were identified from masked grading of retinal photographs. A 145-item self-administered, semiquantitative food frequency questionnaire was completed adequately by 88.8% of participants and was used to assess intakes of dietary fat and fish.

Results  A higher frequency of fish consumption was associated with decreased odds of late ARM (odds ratio for frequency of consumption more than once per week compared with less than once per month, 0.5). Subjects with higher energy-adjusted intakes of cholesterol were significantly more likely to have late ARM, with an increased risk for late ARM for the highest compared with the lowest quintile of intake (odds ratio, 2.7).

Conclusion  The amount and type of dietary fat intake may be associated with ARM.

From the National Centre for Epidemiology and Population Health, Australian National University, Australian Capital Territory (Dr Smith); and the Department of Ophthalmology, Westmead Hospital (Dr Mitchell), and the Department of Public Health and Community Medicine (Dr Leeder), University of Sydney, Sydney, New South Wales, Australia.

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