This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on ISI (5)  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal  Topic Collections  • Hematology/ Hematologic Malignancies  • Leukemias/ Lymphomas  • Alert me on articles by topic

Noemi Lois, MD; Paul S. Hiscott, FRCS, FRCOphth; John Nash, FRCPath; David Wong, FRCS, FRCOphth

Arch Ophthalmol. 2000;118:1692-1694.

The case of an 82-year-old man who developed intraocular extension from mycosis fungoides, a cutaneous T-cell lymphoma, is presented. The patient died soon after intraocular involvement occurred. Immunohistochemistry of a skin biopsy, taken early in the course of the disease, disclosed a predominance of T cells with a helper/inducer phenotype (CD4⁺). However, an intraocular infiltrate obtained 7 years later contained mostly T cells with a suppressor/cytotoxic phenotype (CD8⁺). The occurrence of ocular invasion, the change in immunophenotype, and the predominant proliferation of CD8⁺ lymphocytes may have been related to the poor outcome in this patient.

From the Vitreo-Retinal Service, St Paul's Eye Unit (Drs Lois, Hiscott, and Wong), and the Pathology Department (Drs Hiscott and Nash), The Royal Liverpool University Hospital, Liverpool, England. Dr Lois is now with the Retina Service, Ophthalmology Department, Aberdeen Royal Infirmary, Foresterhill, Aberdeen, Scotland.

RELATED ARTICLE

Archives of Ophthalmology Reader's Choice: Continuing Medical Education
Arch Ophthalmol. 2000;118(12):1714.
FULL TEXT