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Daniel J. Plummer, PhD; Alay Banker, MD; Ibrahim Taskintuna, MD; Stanley P. Azen, PhD; Pamela A. Sample, PhD; Laurie LaBree, MS; William R. Freeman, MD

Arch Ophthalmol. 1999;117:202-207.

Objective  To determine the sensitivity and specificity of entoptic perimetry as a noninvasive test for detecting retinal damage due to peripheral cytomegalovirus (CMV) retinitis.

Design  A masked study comparing entoptic perimetry with fundus photography under 4 experimental conditions (determined by increasing pixel sizes) on 2 separate testing sessions.

Setting  Acquired immunodeficiency syndrome Ocular Research Unit at the University of California, San Diego.

Patients  Twenty-four human immunodeficiency virus–positive and 8 human immunodeficiency virus–negative subjects; 21 eyes with documented CMV retinitis, and 26 eyes that were retinitis free.

Intervention  None.

Measurements  For each testing session, screening method, and condition, the presence of CMV retinitis was determined for each meridian (ie, clock hour), each quadrant (consisting of 3 meridians), and each eye (consisting of all meridians); the amount of retinitis was defined as the percentage of meridians or quadrants with CMV retinitis.

Results  Entoptic perimetry was as sensitive and specific as fundus photography in determining the presence of CMV retinitis. Determination of the amount of CMV retinitis tended to be underestimated by perimetry for larger pixel sizes.

Conclusion  Entoptic perimetry may be an effective and inexpensive alternative to fundus photography for CMV retinitis in hospitals and community clinics.

From the Shiley Eye Center, Department of Ophthalmology, School of Medicine, University of California San Diego, La Jolla (Drs Plummer, Banker, Taskintuna, Azen, Sample, and Freeman and Ms LaBree); and the Statistical Consultation and Research Center, Department of Preventive Medicine, University of Southern California, Los Angeles (Dr Azen and Ms LaBree).

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