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Arch Ophthalmol. 1999;117:1641-1645.

Patients with systemic cancer may have a variety of ocular complaints. Most commonly these are metastases or adverse effects of therapy. Paraneoplastic syndromes, like cancer-associated retinopathy, rarely cause ophthalmic symptoms. We describe a patient with a malignant mixed müllerian tumor and cancer-associated retinopathy who had circulating serum antibodies to recoverin and cells positive for recoverin in the tumor. We discuss the typical clinical symptoms as well as the pathophysiology of this uncommon disorder.

Scott M. Goldstein, MD; Nasreen A. Syed, MD; Ann H. Milam, PhD; Albert M. Maguire, MD; Thomas J. Lawton, MD; Charles W. Nichols, MD
From the Departments of Ophthalmology (Drs Goldstein, Syed, Milam, Maguire, and Nichols) and Pathology and Laboratory Medicine (Drs Syed and Lawton), Scheie Eye Institute and the Hospital of the University of Pennsylvania, Philadelphia.

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