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Arch Ophthalmol. 1999;117:1553-1556.

Choroidal melanoma primarily metastasizes to the liver. Isolated extrahepatic metastases have rarely been reported and they generally resulted in death within 6 months. We describe a patient who developed an isolated brain metastasis 27 years after his left eye was enucleated for choroidal melanoma. The metastasis was succesfully treated with surgery and radiotherapy. The patient is alive and disease free 3 years after treatment of the metastasis. Posterior location and other clinical and morphologic characteristics of primary choroidal melanoma could explain the unusually long latency of this solitary extrahepatic metastatic disease. Lifelong surveillance to detect early signs of metastasis is mandatory for any patient treated for choroidal melanoma.

Edoardo Midena, MD; Valentina de Belvis, MD; Angelo P. Dei Tos, MD; Cristina Antonini, MD
From the Ocular Oncology Service, Institute of Ophthalmology, University of Padova, Padova, Italy (Drs Midena and de Belvis); the Department of Pathology, Treviso General Hospital, Treviso, Italy (Dr Dei Tos); and the San Donà di Piave General Hospital, San Donà di Piave, Italy (Dr Antonini).

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