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Robert N. Weinreb, MD; Leonard A. Levin, MD, PhD

Arch Ophthalmol. 1999;117:1540-1544.

Treatment of glaucoma continues to be directed at lowering intraocular pressure to decrease the likelihood of disease progression. In the future intraocular pressure reduction might be augmented by other therapeutic approaches. Interest has been increasing in preventing progression of glaucomatous optic neuropathy using approaches based on the premise that glaucoma is a neurodegenerative disease. Neuroprotection of the glaucomatous optic nerve therefore would be an adjuctive therapeutic paradigm for use with conventional intraocular pressure–lowering treatments or by itself.

From the Glaucoma Center and Department of Ophthalmology, University of California, San Diego, La Jolla (Dr Weinreb); and Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison (Dr Levin). Both authors are consultants for several pharmaceutical companies involved with potential neuroprotective drugs. Dr Weinreb has served as a consultant or received research support from companies including Alcon Laboratories Inc, Allergan Inc, Merck & Co Inc, and Pharmacia & Upjohn.

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