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Johan Stjernschantz, MD, PhD; Göran Selén, PhD; Maria Astin, PhD; Maritha Karlsson; Bahram Resul, PhD

Arch Ophthalmol. 1999;117:1363-1367.

Objective  To evaluate the effects of latanoprost on regional blood flow and capillary permeability in the monkey eye.

Methods  Anesthetized cynomolgus monkeys were unilaterally treated with a single dose containing 6 µg of latanoprost; or 10 µg of PhXA34 (13,14-dihydro-15R, S-17-phenyl-18,19,20-trinor-prostaglandin F₂ [PGF₂]-isopropyl ester), which contains about 50% latanoprost. Regional blood flow in the eye was measured with radioactively labeled microspheres; capillary permeability was measured by determining the extravascular plasma-equivalent albumin space using ¹²⁵I-albumin, ¹³¹I-albumin, and ⁵¹Cr-labeled erythrocytes.

Results  Latanoprost or PhXA34 had no or only a slight effect on the regional blood flow when measured 1, 2, 3, 4, and 6 hours after dose administration, with the exception of the anterior sclera, in which a moderate increase in blood flow was detected. No effect on capillary permeability to albumin was detected when studied 30 minutes to 2 hours and 5 to 6 hours after dose administration.

Conclusion  Latanoprost, a selective prostaglandin F receptor agonist, exerted no or only slight vascular effects for up to 6 hours after dose administration in the monkey eye, with the exception of the anterior sclera, in which a moderate increase in blood flow was detected.

Clinical Relevance  Naturally occurring prostaglandins may cause marked microcirculatory changes in the eye that could be of clinical concern. Latanoprost, a selective prostaglandin F receptor agonist, seems to be devoid of such effects.

From the Department of Neuroscience, Unit of Pharmacology, Uppsala University (Drs Stjernschantz and Resul), and the Research Laboratories of Pharmacia & Upjohn (Drs Selén and Astin and Ms Karlsson), Uppsala, Sweden. All authors were employees of Pharmacia & Upjohn at the time of the study. None of the authors have any proprietary interest in latanoprost.

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