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Robert A. Mittra, MD; Linh T. Huynh, MD; Mark S. Ruttum, MD; William F. Mieler, MD; Thomas B. Connor, MD; Dennis P. Han, MD; Jose S. Pulido, MD; Sundeep Dev, MD

Arch Ophthalmol. 1998;116:1190-1194.

Objective  To determine the visual outcome after surgery for persistent hyperplastic primary vitreous using modern vitreoretinal techniques.

Design  Retrospective medical record review during a 5-year period (June 1992 to June 1997). Information recorded for each patient included age, medical history, sex, results of preoperative ocular examination, age at diagnosis, procedure performed, intraoperative and postoperative complications, location and number of sclerotomy sites, type of aphakic rehabilitation, amblyopic therapy given, final visual acuity, and length of follow-up.

Results  Fourteen patients who underwent surgical management of combined anterior and posterior persistent hyperplastic primary vitreous were identified. Eleven patients underwent aphakic rehabilitation and aggressive amblyopic therapy consisting of occlusive therapy for several waking hours each day. One additional older patient received aphakic rehabilitation only. Ten eyes (71%) achieved a visual acuity of 20/300 or better, and 8 (57%) obtained a final visual acuity of 20/100 or better. Average length of follow-up was 22 months (range, 4-57 months). Nine patients were fitted with an aphakic soft contact lens, 2 older patients had a posterior chamber intraocular lens placed at the time of vitrectomy, and 1 patient wore aphakic spectacles.

Conclusions  With modern vitreoretinal techniques, aphakic rehabilitation, and aggressive amblyopic therapy, useful vision can be obtained in the majority of patients with combined anterior and posterior persistent hyperplastic primary vitreous.

From the Eye Institute, Vitreoretinal and Pediatric Sections, Medical College of Wisconsin, Milwaukee.

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